The degradation of DNA by hydrazine: identification of 3-ureidopyrazole as a product of the hydrazinolysis of deoxycytidylic acid residues
| Autor: | A.R. Cashmore, George B. Petersen |
|---|---|
| Rok vydání: | 1978 |
| Předmět: |
DNA
Bacterial Chemical Phenomena Spectrophotometry Infrared Hydrazine Thymus Gland Biology Mass spectrometry Mass Spectrometry chemistry.chemical_compound Genetics Escherichia coli Animals Deoxycytidine monophosphate DNA Chemistry Hydrazines chemistry Biochemistry Deoxycytosine Nucleotides Yield (chemistry) Cattle Hydrate Cytosine Nuclear chemistry |
| Zdroj: | Nucleic acids research. 5(7) |
| ISSN: | 0305-1048 |
| Popis: | The reaction of hydrazine with the cytosine residues of DNA yields 3-ureidopyrazole, in approximately 50% yield, in addition to the expected 3-aminopyrazole. This product has been identified by ultraviolet, infrared, nuclear magnetic resonance and mass spectroscopy. A product of the reaction of hydrazine hydrate with cytosine, formulated by others as NN'-di-(3-pyrazolyl) hydrazine, has been identified as 3-ureidopyrazole. |
| Databáze: | OpenAIRE |
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