Unconjugated bisphenol A cord blood levels in boys with descended or undescended testes
| Autor: | Kathy Wagner-Mahler, J. Gal, Patricia Pacini, C. Harthe, H. Dechaux, Patrick Fénichel, Michel Pugeat, Françoise Brucker-Davis, Patricia Ferrari |
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| Rok vydání: | 2012 |
| Předmět: |
Boron Compounds
Male medicine.medical_specialty Phenylalanine Endocrine Disruptors Mass Spectrometry Endocrine disrupting compound Pregnancy Internal medicine Cryptorchidism medicine Humans Testosterone Chromatography High Pressure Liquid Fetus Milk Human business.industry Rehabilitation Infant Newborn Obstetrics and Gynecology Radioimmunoassay Environmental exposure Environmental Exposure Fetal Blood Endocrinology Reproductive Medicine Cord blood Prenatal Exposure Delayed Effects Gestation Female business Hormone |
| Zdroj: | Human reproduction (Oxford, England). 27(4) |
| ISSN: | 1460-2350 |
| Popis: | background: Human toxicity of bisphenol A (BPA), a weak estrogenic environmental endocrine disrupting compound, widely used in plastics, baby bottles, cans and dental sealants, is under investigation. Fetal or perinatal exposure in rodents is associated with programmed adult reproductive diseases. Human epidemiological studies remain scarce, especially concerning testicular development. We have investigated the relationship between fetal exposure to BPA and cryptorchidism. methods: Using a radioimmunoassay performed after extraction, validated by high-performance liquid chromatography and mass spectrometry, active levels of unconjugated BPA (uBPA) in cord blood (CB) were measured in 152 boys born after 34 weeks gestation, with cryptorchid or descended testes. results: Active uBPA was detectable in all CB samples, with values in the control group (n ¼ 106) of 0.14–4.76 ng/ml, median: 0.9 ng/ ml; mean+ SD: 1.12 ng/ml+ 0.86 ng/ml, which did not differ from cryptorchid boys (n ¼ 46, 1.26+ 1.13 ng/ml, P ¼ 0.38). uBPA in controls correlated with CB inhibin B (P , 0.01) and total testosterone (P , 0.05), and with maternal milk polychlorinated bisphenyl 138 (P , 0.03). uBPA did not correlate with clinical maternal or fetal parameters or with other steroid or polypeptide CB hormones assessed. conclusions: The presence of uBPA in all CB samples suggests placental transfer and fetal exposure. Similar uBPA levels in the control and cryptorchid groups make the participation of fetal exposure to uBPA in the physiopathology of undescended testes unlikely. However, the observed nanomolar uBPA concentrations support assessment of epidemiological relationships between CB uBPA and other human diseases. |
| Databáze: | OpenAIRE |
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