Nodal positivity in breast cancer correlated with the number of lesions detected by magnetic resonance imaging versus mammogram
| Autor: | Rohil Shekher, A. Korant, Mohammed Kanaan, S. Sirop, Linda Lawrence, Randy Hicks, Michael Hicks, Sukamal Saha, David Strahle, David Wiese |
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| Rok vydání: | 2011 |
| Předmět: |
Adult
medicine.medical_specialty Mammary gland Breast Neoplasms Risk Assessment Lesion Breast cancer Predictive Value of Tests Risk Factors medicine Humans Mammography Lymph node Aged Retrospective Studies medicine.diagnostic_test business.industry Cancer Magnetic resonance imaging General Medicine Middle Aged Prognosis medicine.disease Magnetic Resonance Imaging medicine.anatomical_structure Lymphatic Metastasis Female Surgery Lymph Nodes Breast disease Radiology medicine.symptom business |
| Zdroj: | The American Journal of Surgery. 201:390-395 |
| ISSN: | 0002-9610 |
| DOI: | 10.1016/j.amjsurg.2010.11.006 |
| Popis: | Background Magnetic resonance imaging (MRI) in breast cancer can detect more than 15% additional lesions than mammography. We investigated lymph node metastases rates in patients with multifocal or multicentric disease detected by MRI compared with patients with a single lesion detected by mammography and magnetic resonance imaging. Methods A retrospective analysis of breast cancer patients undergoing MRI and mammography was performed. The objective was to compare lymph node metastases rates in patients with additional lesions detected by MRI versus a single lesion detected by mammography or MRI. Results Of 413 patients, 318 were included for the study. The overall nodal metastases rate was 24.8%. MRI detected multiple lesions in 83 (26.1%) patients; 67 (21.1%) patient MRI findings were not detected by mammography. The lymph node metastases rate was 37.3% when ≥2 lesions were detected compared with 20.2% when a single malignant lesion was detected ( P = .01). The evaluation of the 67 patients with additional lesions detected by MRI revealed 32 patients with invasive lesions, 29 with benign lesions, and 6 with in situ disease. Comparing patients with single malignant lesions with patients with additional malignant lesions detected by MRI, the lymph node metastases rate increased from 20.2% to 50% ( P = .002). Conclusions Our study shows a significant increase in the lymph node metastases rate in patients with additional malignant lesions detected by MRI. This finding suggests that MRI-detected malignant lesions are biologically significant and may predict more aggressive disease. |
| Databáze: | OpenAIRE |
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