Stromal Cell Derived Factor-1-Mediated Migration of Mesenchymal Stem Cells Enhances Collagen Type II Expression in Intervertebral Disc
| Autor: | Matteo D'Este, Raquel Gonçalves, Catarina Leite Pereira, David Eglin, Sibylle Grad, Graciosa Q. Teixeira, Maulo Alini, Mário A. Barbosa, Joana R. Ferreira |
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| Rok vydání: | 2018 |
| Předmět: |
musculoskeletal diseases
0301 basic medicine Programmed cell death Cell Biomedical Engineering Bioengineering 02 engineering and technology Biochemistry Biomaterials Extracellular matrix 03 medical and health sciences medicine Stromal cell-derived factor 1 biology Chemistry Catabolism Regeneration (biology) Mesenchymal stem cell Intervertebral disc musculoskeletal system 021001 nanoscience & nanotechnology Cell biology 030104 developmental biology medicine.anatomical_structure biology.protein 0210 nano-technology |
| Zdroj: | Tissue engineering. Part A. |
| ISSN: | 1937-335X |
| Popis: | Intervertebral disc (IVD) degeneration is characterized by an unbalanced cell catabolic/anabolic activity and cell death, resulting in the degradation of extracellular matrix components and water loss. Repopulating the IVD with new cells may help in recovering tissue homeostasis and reverting the degenerative process. In this study the regenerative potential of a hyaluronan (HA)-based chemoattractant delivery system able to recruit mesenchymal stem cells (MSCs) seeded on the cartilaginous endplate (CEP) of IVD was explored. A HA delivery system containing stromal cell derived factor-1 (SDF-1) (5 ng/μL) (HAPSDF5) was injected in the cavity of nucleotomized bovine discs. Human MSCs (1 × 10 |
| Databáze: | OpenAIRE |
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