A case of rheumatoid arthritis complicated with salazosulfapyridine-induced aplastic anemia
| Autor: | Michito Hirakata, Akira Suwa, Shinichi Kawai, Arikuni Nakamura, Shinichi Inada |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
medicine.medical_specialty
Blood transfusion Anemia medicine.medical_treatment Immunology Arthritis Platelet Transfusion Gastroenterology Arthritis Rheumatoid Blood Transfusion Autologous Internal medicine White blood cell medicine Humans Immunology and Allergy Peripheral blood cell Aplastic anemia business.industry Anemia Aplastic General Medicine Middle Aged medicine.disease Sulfasalazine medicine.anatomical_structure Antirheumatic Agents Rheumatoid arthritis Prednisolone Female Erythrocyte Transfusion business medicine.drug |
| Zdroj: | Japanese Journal of Clinical Immunology. 18:116-122 |
| ISSN: | 1349-7413 0911-4300 |
| DOI: | 10.2177/jsci.18.116 |
| Popis: | A 64 year-old woman with rheumatoid arthritis was admitted to our hospital because of general fatigue. She noticed polyarthralgia 8 months prior to the admission and diagnosis of rheumatoid arthritis was made. Administration of salazosulfapyridine (1.0 g/day) was started 6 months before the admission. Complete remission of rheumatoid arthritis was obtained in 2 months and blood cell counts showed normal values at that time. The results of laboratory tests included hemoglobin; 8.6 g/dl, white blood cell count; 1,900/mm3 with a differential of 19% neutrophils, 77% lymphocytes, and 4% monocytes; platelets were 21,000/mm3. A bone marrow aspiration and biopsy were performed. There were reduced numbers of myelocytes, erythroblasts, and megakaryocytes indicating aplastic anemia. Salazosulfapyridine was discontinued. Prednisolone, anabolic steroid and granulocyte-colony stimulating factor (G-CSF) were administrated. In spite of these therapy, recovery of peripheral blood cell counts have not been observed and supporting therapy including red cell and platelets transfusion have been continued. To our knowledge, this is the first case report which describes occurrence of aplastic anemia in patients with rheumatoid arthritis treated by salazosulfapyridine. |
| Databáze: | OpenAIRE |
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