Wnt pathway components orient a mitotic spindle in the early Caenorhabditis elegans embryo without requiring gene transcription in the responding cell
| Autor: | Bruce Bowerman, Julin N. Maloof, Christopher A. Shelton, Marc D. Meneghini, Ann Schlesinger |
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| Předmět: |
Blastomeres
Embryo Nonmammalian Cell division Transcription Genetic Molecular Sequence Data Embryonic Development Helminth genetics Spindle Apparatus Spindle pole body Glycogen Synthase Kinase 3 Proto-Oncogene Proteins Cell polarity Genetics medicine Animals Cell Lineage Amino Acid Sequence Caenorhabditis elegans Cells Cultured Cytoskeleton Genes Helminth biology Sequence Homology Amino Acid Stem Cells Endoderm Wnt signaling pathway Cell Polarity Helminth Proteins Zebrafish Proteins biology.organism_classification Cell biology Spindle apparatus Wnt Proteins medicine.anatomical_structure embryonic structures Calcium-Calmodulin-Dependent Protein Kinases Mutation Developmental Biology Research Paper Signal Transduction |
| Zdroj: | Scopus-Elsevier |
| Popis: | In a four-cell-stage Caenorhabditis elegans embryo, Wnt signaling polarizes an endoderm precursor called EMS. The polarization of this cell orients its mitotic spindle in addition to inducing endodermal fate in one daughter cell. Reducing the function of Wnt pathway genes, including a newly identified GSK-3beta homolog called gsk-3, disrupts endoderm induction, whereas only a subset of these genes is required for proper EMS mitotic spindle orientation. Wnt pathway genes thought to act downstream of gsk-3 appear not to be required for spindle orientation, suggesting that gsk-3 represents a branch point in the control of endoderm induction and spindle orientation. Orientation of the mitotic spindle does not require gene transcription in EMS, suggesting that Wnt signaling may directly target the cytoskeleton in a responding cell. |
| Databáze: | OpenAIRE |
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