The role of anxiety in cortisol stress response and cortisol recovery in boys with oppositional defiant disorder/conduct disorder
| Autor: | Schoorl, Jantiene, van Rijn, S., de Wied, M., van Goozen, S.H.M., Swaab, Hanna, Adolescent development: Characteristics and determinants, Leerstoel Branje |
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| Přispěvatelé: | Adolescent development: Characteristics and determinants, Leerstoel Branje |
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Male
medicine.medical_specialty endocrine system Hydrocortisone Endocrinology Diabetes and Metabolism Comorbidity Anxiety Stress Oppositional defiant disorder Conduct disorder Fight-or-flight response 03 medical and health sciences 0302 clinical medicine Endocrinology Internal medicine mental disorders medicine Humans 0501 psychology and cognitive sciences Cortisol stress reactivity Psychiatry Child Biological Psychiatry Cortisol recovery Endocrine and Autonomic Systems 05 social sciences Stressor medicine.disease Psychiatry and Mental health Attention Deficit and Disruptive Behavior Disorders Oppositional defiant medicine.symptom Psychology Psychosocial 030217 neurology & neurosurgery Stress Psychological hormones hormone substitutes and hormone antagonists 050104 developmental & child psychology medicine.drug |
| Zdroj: | Psychoneuroendocrinology, 73, 217. Elsevier |
| ISSN: | 0306-4530 |
| Popis: | Children with antisocial and aggressive behaviors have been found to show abnormal neurobiological responses to stress, specifically impaired cortisol stress reactivity. The role of individual characteristics, such as comorbid anxiety, in the stress response is far less studied. Furthermore, this study extended previous studies in that not only baseline and reactivity to a psychosocial stressor were examined, but also recovery from a stressor. These three phases of cortisol could be impacted differentially in boys with oppositional defiant disorder/conduct disorder (ODD/CD) with (+ANX) and without anxiety (−ANX). The results revealed that cortisol patterns in response to psychosocial stress were different for boys with ODD/CD + ANX (n = 32), ODD/CD-ANX (n = 22) and non-clinical controls (NC) (n = 34), with age range of 7.8–12.9 years. The ODD/CD-ANX group showed lower overall cortisol levels than the NC group. When considering the three phases of cortisol separately, the ODD/CD-ANX group had lower baseline cortisol levels relative to the other groups, whereas the ODD/CD + ANX showed an impaired cortisol recovery response. Within those with ODD/CD, callous-unemotional traits were predictive of high baseline cortisol levels. Also, anxiety predicted high baseline and recovery cortisol levels, whereas a high number of CD symptoms predicted reduced cortisol stress reactivity. These results clearly indicate that comorbid anxiety is an important factor in explaining differences in stress response profiles in boys with ODD/CD; although boys with CD/ODD are generally characterized by an impaired cortisol stress response, we found that those with comorbid anxiety showed impaired cortisol recovery, whereas those without anxiety showed reduced baseline cortisol levels. |
| Databáze: | OpenAIRE |
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