Response inhibition in borderline personality disorder: Neural and behavioral correlates
| Autor: | Luis Carretié, Nerea Palomares, Jacobo Albert, Sara López-Martín, Sandra Hoyos, Marina Díaz-Marsá, José L. Carrasco, Rocío Arza |
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| Rok vydání: | 2018 |
| Předmět: |
Adult
Male medicine.medical_specialty Dissociation (neuropsychology) Brain activity and meditation Precuneus Prefrontal Cortex Audiology Electroencephalography behavioral disciplines and activities 050105 experimental psychology 03 medical and health sciences 0302 clinical medicine Borderline Personality Disorder Parietal Lobe mental disorders Task Performance and Analysis medicine Humans 0501 psychology and cognitive sciences Borderline personality disorder Evoked Potentials Response inhibition medicine.diagnostic_test business.industry General Neuroscience 05 social sciences Brain Neurophysiology medicine.disease Inhibition Psychological Neuropsychology and Physiological Psychology medicine.anatomical_structure Scalp Case-Control Studies Female business 030217 neurology & neurosurgery |
| Zdroj: | Biological psychology. 143 |
| ISSN: | 1873-6246 |
| Popis: | Although response inhibition is thought to be important in borderline personality disorder (BPD), little is known about its neurophysiological basis. This study aimed to provide insight into this issue by capitalizaing on the high temporal resolution of electroencephalography and information provided by source localization methods. To this end, twenty unmedicated patients with BPD and 20 healthy control subjects performed a modified go/no-go task designed to better isolate the brain activity specifically associated with response inhibition. Event-related potentials (ERP) were measured and further analyzed at the scalp and source levels. Patients with BPD made more commission errors (failed inhibitions) than control subjects. Scalp ERP data showed that both groups displayed greater frontocentral P3 amplitude for no-go (response inhbition) than for go trials (response execution). However, source reconstruction data revealed that patients with BPD activated posterior parietal regions (precuneus) to inhibit their responses, whereas controls activated prefrontal regions (presupplementary motor area, preSMA). This dissociation was supported by a significant Region (precuneus, preSMA) x Trial Type (no-go, go) x Group (BPD, control) interaction. These findings extend our understanding of the neurophysiological basis of abnormal response inhibition in BPD, suggesting that patients with BPD recruit different brain regions for inhibiting prepotent responses compared to controls. Future research in larger, medication-naive samples of patients with BPD is required to confirm and extend these findings. |
| Databáze: | OpenAIRE |
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