Effect of Antiretroviral Therapy on HIV Reservoirs in Elite Controllers
| Autor: | Rupert Kaul, Connie J. Kim, Susan Moir, Cecilia T. Costiniuk, Gabor Kandel, Joseph P. Casazza, Erika Benko, Tae-Wook Chun, Colin Kovacs, Mario A. Ostrowski, Richard A. Koup, Jana Blazkova, J. Shawn Justement, Claire W. Hallahan, Anthony S. Fauci, Danielle Murray |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
CD4-Positive T-Lymphocytes
Anti-HIV Agents CD4-CD8 Ratio Organophosphonates Human immunodeficiency virus (HIV) HIV Infections Viremia Biology Virus Replication medicine.disease_cause Deoxycytidine Major Articles and Brief Reports Raltegravir Potassium medicine Emtricitabine Humans Immunology and Allergy Dna viral Tenofovir Adenine virus diseases medicine.disease Antiretroviral therapy Virology Immunity Innate Pyrrolidinones Discontinuation Infectious Diseases Viral replication Asymptomatic Diseases DNA Viral Immunology HIV-1 Drug Therapy Combination Elite controllers |
| Zdroj: | The Journal of Infectious Diseases. 208:1443-1447 |
| ISSN: | 1537-6613 0022-1899 |
| DOI: | 10.1093/infdis/jit306 |
| Popis: | Elite controllers suppress human immunodeficiency virus (HIV) viremia to below the limit of detection in the absence of antiretroviral therapy (ART). However, precise frequencies of CD4(+) T cells carrying replication-competent HIV and/or the dynamics of the infectious viral reservoirs in response to initiation and discontinuation of ART in elite controllers are unknown. We show that the size of the pool of CD4(+) T cells harboring infectious HIV diminished significantly after initiation of ART and rebounded to baseline upon cessation of therapy. Our data provide compelling evidence that persistent viral replication occurs in untreated elite controllers even in the absence of detectable plasma viremia. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|