Pharmacokinetics and Disposition of Circulating Iridoids and Organic Acids in Rats Intravenously Receiving ReDuNing Injection
| Autor: | Wei Xiao, Chengchun Zhong, Ke Yu, Chen Cheng, Junling Yang, Qiongwei Liu, Olajide E. Olaleye, Zhen-zhong Wang, Feng Chen, Fengqing Wang, Jing Li, Chuan Li, Fang Xu, Feifei Du, Li Li |
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| Rok vydání: | 2016 |
| Předmět: |
Male
Pharmaceutical Science Gardenia jasminoides Pharmacology 030226 pharmacology & pharmacy 01 natural sciences Injections Rats Sprague-Dawley 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Sulfation Pharmacokinetics Chlorogenic acid Animals Iridoids Flavonoids Neochlorogenic acid biology Chemistry 010401 analytical chemistry Metabolism Quinic acid biology.organism_classification 0104 chemical sciences Rats Renal physiology Administration Intravenous Acids Half-Life |
| Zdroj: | Drug metabolism and disposition: the biological fate of chemicals. 44(11) |
| ISSN: | 1521-009X |
| Popis: | ReDuNing injection, prepared from a combination of Gardenia Jasminoides fruits, Lonicera japonica flower buds, and the Artemisia annua aerial part, is extensively used for treatment of viral upper respiratory tract infections in China. Iridoids, organic acids, and flavonoids are likely important compounds of the herbal injection because of their reported pharmacological properties. This study was designed to characterize pharmacokinetics and disposition of the major circulating herbal compounds in rats that received the injection intravenously. ReDuNing injection was found to contain 19 iridoids (content levels 0.01-27.93 mM), 16 organic acids (0.04-19.06 mM), and 11 flavonoids ( |
| Databáze: | OpenAIRE |
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