Water extract of Pueraria lobata Ohwi has anti-viral activity against human respiratory syncytial virus in human respiratory tract cell lines
| Autor: | Jih-Jin Tsai, Kuo-Chih Wang, Chia-Feng Yeh, Jung-San Chang, Lien-Chai Chiang, Tzeng-Jih Lin |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Pueraria
Respiratory tract infection Viral Plaque Assay Antiviral Agents Chemoprevention Ge-Gen-Tang Virus Microbiology chemistry.chemical_compound Lobata medicine Human respiratory syncytial virus Humans Respiratory system Medicine(all) lcsh:R5-920 biology Pueraria lobata business.industry Plant Extracts Ribavirin General Medicine Interferon-beta medicine.disease biology.organism_classification Virology Respiratory Syncytial Viruses medicine.anatomical_structure chemistry Bronchiolitis Cell culture business lcsh:Medicine (General) Respiratory tract |
| Zdroj: | Kaohsiung Journal of Medical Sciences, Vol 29, Iss 12, Pp 651-657 (2013) |
| ISSN: | 1607-551X |
| DOI: | 10.1016/j.kjms.2013.06.001 |
| Popis: | Human respiratory syncytial virus (HRSV) infects all age groups and causes bronchiolitis, pneumonia, and acute respiratory distress syndrome with a significant mortality rate. To date, only ribavirin has been used to manage HRSV infection. However, ribavirin is expensive with an only modest effect. Furthermore, ribavirin has several side effects, which means it has limited clinical benefit. Pueraria lobata Ohwi (P. lobata) is a common ingredient of Ge-Gen-Tang (Kakkon-to) and Sheng-Ma-Ge-Gen-Tang (Shoma-kakkon-to), which are prescriptions of Chinese traditional medicine proven to have antiviral activity against HRSV. Therefore, it was hypothesized that P. lobata might be effective against HRSV. To find a cost-effective therapeutic modality, both human upper (HEp-2) and lower (A549) respiratory tract cell lines were used to test the hypothesis that P. lobata could inhibit HRSV-induced plaque formation. Results showed that the water extract of P. lobata was effective (p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text