T cell determinants of myelin basic protein include a unique encephalitogenic I-E-restricted epitope for Lewis rats
| Autor: | F. R. Burns, A. Galang, E. Heber-Katz, G. A. Hashim, B. Celnik, Xiaobin Li, Arthur A. Vandenbark, Ning Shen, Halina Offner |
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| Rok vydání: | 1989 |
| Předmět: |
Encephalomyelitis
Autoimmune Experimental Time Factors T-Lymphocytes T cell Molecular Sequence Data Immunology Biology Epitope Epitopes Antigen medicine Animals Immunology and Allergy Hypersensitivity Delayed Amino Acid Sequence Peptide sequence T-cell receptor Histocompatibility Antigens Class II Myelin Basic Protein Articles T lymphocyte Molecular biology Clone Cells Rats Myelin basic protein medicine.anatomical_structure Biochemistry Rats Inbred Lew Delayed hypersensitivity biology.protein Immunologic Memory |
| Zdroj: | The Journal of Experimental Medicine |
| ISSN: | 1540-9538 0022-1007 |
| DOI: | 10.1084/jem.170.2.355 |
| Popis: | The major encephalitogenic epitope for Lewis rats is the 72-89 sequence of guinea pig basic protein (GP-BP) or rat basic protein (Rt-BP). T cells responsive to this epitope are I-A restricted and preferentially express the V alpha 2:V beta 8 gene combination in their TCR. In this work, we describe for the first time the delayed appearance of T cells specific for additional discrete determinant of BP, the nonencephalitogenic 55-68 sequence of GP-BP restricted by I-A, and the encephalitogenic 87-99 sequence of Rt-BP restricted by I-E. The TCR V alpha 2:V beta 8 gene combination was expressed by both encephalitogenic GP-BP S72-89 and Rt-BP S87-99 T cell specificities but not by GP-BP 44-68-specific T cells. This is the first demonstration of I-E-restricted encephalitogenic T cells in Lewis rats and supports the conclusion that the I-E class II locus is involved in autoimmune diseases. |
| Databáze: | OpenAIRE |
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