Cytotoxic Limonoids from Melia azedarach
| Autor: | Hui-Ming Hua, Shun-Lin Li, Xiao-Jiang Hao, Xing-Yao Li, Gui-Hua Tang, Yan Li, Shi-Fei Li, Yu Zhang, Hongping He, Ying-Tong Di, Li Hou, Chun-Mao Yuan |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Limonins
Magnetic Resonance Spectroscopy Stereochemistry Melia azedarach medicine.medical_treatment Pharmaceutical Science Mass Spectrometry Analytical Chemistry Steroid Inhibitory Concentration 50 Structure-Activity Relationship Cell Line Tumor Drug Discovery Ic50 values medicine Humans Cytotoxic T cell MTT assay Pharmacology Meliaceae Molecular Structure biology Plant Extracts Chemistry Organic Chemistry biology.organism_classification Antineoplastic Agents Phytogenic Triterpenes Complementary and alternative medicine visual_art Plant Bark visual_art.visual_art_medium Molecular Medicine Steroids Bark Drug Screening Assays Antitumor Sesquiterpenes Two-dimensional nuclear magnetic resonance spectroscopy |
| Zdroj: | Planta Medica. 79:163-168 |
| ISSN: | 1439-0221 0032-0943 |
| DOI: | 10.1055/s-0032-1328069 |
| Popis: | Five new compounds (1-5), including two limonoids, one triterpenoid, one steroid, and one sesquiterpenoid, along with nine known limonoids (6-14), were isolated from the bark of Melia azedarach. The structures of the new compounds were elucidated by 2D NMR spectroscopy and mass spectrometry. The isolated compounds as well as three acetylated derivatives of 9 were evaluated for their cytotoxicities against five human tumor cell lines (HL-60, SMMC-7721, A-549, MCF-7, and SW480) by an MTT assay. Seven limonoids (1, 6, 7, 8, 9, 9b, and 9c) showed significant inhibitory activities against tested cell lines with IC50 values ranging from 0.003 to 0.555 mu M, and their preliminary structure-activity relationships are also discussed. |
| Databáze: | OpenAIRE |
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