Mutational analysis of phospholipase A2A: a positional candidate susceptibility gene for bipolar disorder
| Autor: | Michael John Owen, E. K. Franks, N. J. Jacobsen, Nicholas John Craddock |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
Adult
Genetic Markers Male Bipolar Disorder Genotype Cosegregation DNA Mutational Analysis Restriction Mapping Locus (genetics) Biology Polymerase Chain Reaction Linkage Disequilibrium Phospholipases A Genetic determinism Cellular and Molecular Neuroscience Gene mapping Reference Values Genetic linkage medicine Humans Genetic Predisposition to Disease Bipolar disorder Molecular Biology Genetics Chromosomes Human Pair 12 Polymorphism Genetic Chromosome Mapping Exons medicine.disease Psychiatry and Mental health Genetic marker Female Trinucleotide repeat expansion Darier Disease Polymorphism Restriction Fragment Length |
| Zdroj: | Molecular Psychiatry. 4:274-279 |
| ISSN: | 1476-5578 1359-4184 |
| Popis: | Evidence for the involvement of genetic factors in the pathogenesis of bipolar affective disorder is now well established. However, the mode of inheritance is non-mendelian and this makes the identification of susceptibility loci difficult. A short-cut to localisation of a disease gene for an oligogenic/multifactorial disorder such as bipolar disorder may come from observation of cosegregation with a monogenic trait. We have described a family (pedigree 324) in which there was cosegregation of major affective disorder and Darier's disease, a dominantly inherited skin disorder, and hypothesised that this reflects genetic linkage between genes involved in these disorders. Genetic mapping studies have placed the locus for Darier's disease on chromosome 12q23-q24. We conducted subsequent linkage studies (1995) upon 45 bipolar families (without Darier's disease). These results showed some evidence in favour of linkage with chromosome 12q markers with maximum evidence at a trinucleotide repeat marker within intron 1 of the phospholipase A2A (PLA2A) gene. Evidence for linkage was more significant when analysing the 22 families comprising the Cardiff centre sample, which were expected to be most genetically similar to pedigree 324. |
| Databáze: | OpenAIRE |
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