Case of small bowel perforation secondary to nivolumab and ipilimumab related tumour regression
| Autor: | Lennard Yw Lee, Arvind Tripathy, Kishen Rajan Patel, David McKean |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Male
medicine.medical_specialty Skin Neoplasms Side effect Perforation (oil well) Testicular pain Ipilimumab Anastomosis 030218 nuclear medicine & medical imaging 03 medical and health sciences 0302 clinical medicine Antineoplastic Agents Immunological medicine Humans Melanoma Unexpected Outcome (Positive or Negative) Including Adverse Drug Reactions business.industry General Medicine Middle Aged medicine.disease medicine.anatomical_structure Nivolumab Intestinal Perforation 030220 oncology & carcinogenesis Abdomen Neoplasms Unknown Primary Radiology Immunotherapy Skin cancer medicine.symptom business medicine.drug |
| Zdroj: | BMJ Case Rep |
| ISSN: | 1757-790X |
| Popis: | A 56-year-old man undergoing immunotherapy treatment for metastatic melanoma presented with sudden onset testicular pain radiating into his abdomen. On examination, the abdomen was generally tender with associated guarding. Imaging revealed a perforation of the small bowel at the site of a metastatic lesion. Histology revealed that this process was non-inflammatory in nature. A diagnosis of small bowel perforation secondary to immunotherapy driven rapid tumour regression was made. The patient was treated with a small bowel resection plus anastomosis and made a full recovery. This case highlights the rare potential side effect of immunotherapy in causing non-inflammatory bowel perforations secondary to rapid tumour regression. |
| Databáze: | OpenAIRE |
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