Non-neoplastic lesions of female virgin Han:NMRI mice, incidence and influence of food restriction throughout life span. I: Thyroid
| Autor: | Sabine Rehm, Friedrich Deerberg, Barbara Nitsche |
|---|---|
| Rok vydání: | 1985 |
| Předmět: |
medicine.medical_specialty
Longevity Thyroid Gland Mice Inbred Strains Periodic acid–Schiff stain Biology Distension Rodent Diseases Mice Species Specificity Thinness Internal medicine Ultimopharyngeal body medicine Animals Cyst Obesity General Veterinary Incidence (epidemiology) Thyroid Age Factors medicine.disease Animal Feed Thyroid Diseases Food restriction medicine.anatomical_structure Endocrinology Nmri mice Female Animal Science and Zoology |
| Zdroj: | Laboratory Animals. 19:214-223 |
| ISSN: | 1758-1117 0023-6772 |
| DOI: | 10.1258/002367785780893601 |
| Popis: | A life span study with 900 female virgin Han:NMRI mice (300 outbred controls, 300 of a fat subline and 300 of a lean subline) was carried out to determine the occurrence of spontaneous disease with ad libitum or restricted feeding. The major age-dependent non-neoplastic alteration of the thyroid was a cystic distension of the ultimobranchial bodies (up to 90% in the oldest age groups). Most of the severely cystic thyroids were found in animals of the fat sublines and development seemed to be slightly delayed by food restriction. The cyst walls were composed of ciliated and non-ciliated granular or highly attenuated cells. The cysts contained Alcian blue and periodic acid Schiff positive substances. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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