HNG, A Humanin Analogue, Promotes Hair Growth by Inhibiting Anagen-to-Catagen Transition

Autor: Young Sang Koh, Hee-Kyoung Kang, Sun Kyung Oh, Ji Soo Go, Jung-Il Kang, Eun-Sook Yoo, Youn Kyung Choi, Hoon-Seok Yoon, Jeongtae Kim, Meejung Ahn, Jin Won Hyun, Sung Min Kim
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Male
0301 basic medicine
MAPK/ERK pathway
Apoptosis
lcsh:Chemistry
Mice
chemistry.chemical_compound
0302 clinical medicine
Hair cycle
Skin Physiological Phenomena
STAT3
anagen
lcsh:QH301-705.5
Cells
Cultured
Spectroscopy
biology
integumentary system
Chemistry
Cell Cycle
Intracellular Signaling Peptides and Proteins
Dermis
General Medicine
VEGF
Computer Science Applications
Cell biology
Vascular endothelial growth factor
medicine.anatomical_structure
030220 oncology & carcinogenesis
Female
Hair Follicle
humanin
Article
Catalysis
Inorganic Chemistry
03 medical and health sciences
hair growth
otorhinolaryngologic diseases
medicine
Animals
Rats
Wistar
Physical and Theoretical Chemistry
Molecular Biology
Protein kinase B
Cell Proliferation
Humanin
Cell growth
Organic Chemistry
Hair follicle
Rats
Mice
Inbred C57BL
body regions
030104 developmental biology
lcsh:Biology (General)
lcsh:QD1-999
dermal papilla cells
biology.protein
sense organs
Hair
Zdroj: International Journal of Molecular Sciences, Vol 21, Iss 4553, p 4553 (2020)
International Journal of Molecular Sciences
Volume 21
Issue 12
ISSN: 1661-6596
1422-0067
Popis: The hair follicle goes through repetitive cycles including anagen, catagen, and telogen. The interaction of dermal papilla cells (DPCs) and keratinocytes regulates the hair cycle and hair growth. Humanin was discovered in the surviving brain cells of patients with Alzheimer&rsquo
s disease. HNG, a humanin analogue, activates cell growth, proliferation, and cell cycle progression, and it protects cells from apoptosis. This study was performed to investigate the promoting effect and action mechanisms of HNG on hair growth. HNG significantly increased DPC proliferation. HNG significantly increased hair shaft elongation in vibrissa hair follicle organ culture. In vivo experiment showed that HNG prolonged anagen duration and inhibited hair follicle cell apoptosis, indicating that HNG inhibited the transition from the anagen to catagen phase mice. Furthermore, HNG activated extracellular signal-regulated kinase (Erk)1/2, Akt, and signal transducer and activator of transcription (Stat3) within minutes and up-regulated vascular endothelial growth factor (VEGF) levels on DPCs. This means that HNG could induce the anagen phase longer by up-regulating VEGF, which is a Stat3 target gene and one of the anagen maintenance factors. HNG stimulated the anagen phase longer with VEGF up-regulation, and it prevented apoptosis by activating Erk1/2, Akt, and Stat3 signaling.
Databáze: OpenAIRE
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