Radiomics model of 18F-FDG PET/CT imaging for predicting disease-free survival of early-stage uterine cervical squamous cancer
Autor: | Shuai Liu, Ruikun Li, Qiufang Liu, Dazheng Sun, Hongxing Yang, Herong Pan, Lisheng Wang, Shaoli Song |
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Rok vydání: | 2022 |
Předmět: |
Adult
Aged 80 and over Cancer Research Uterine Cervical Neoplasms General Medicine Middle Aged Prognosis Disease-Free Survival Oncology Fluorodeoxyglucose F18 Positron Emission Tomography Computed Tomography Biomarkers Tumor Carcinoma Squamous Cell Genetics Humans Radiographic Image Interpretation Computer-Assisted Female Radiopharmaceuticals Aged |
Zdroj: | Cancer Biomarkers. 33:249-259 |
ISSN: | 1875-8592 1574-0153 |
Popis: | BACKGROUND: To explore an effective predictive model based on PET/CT radiomics for the prognosis of early-stage uterine cervical squamous cancer. METHODS: Preoperative PET/CT data were collected from 201 uterine cervical squamous cancer patients with stage IB-IIA disease (FIGO 2009) who underwent radical surgery between 2010 and 2015. The tumor regions were manually segmented, and 1318 radiomic features were extracted. First, model-based univariate analysis was performed to exclude features with small correlations. Then, the redundant features were further removed by feature collinearity. Finally, the random survival forest (RSF) was used to assess feature importance for multivariate analysis. The prognostic models were established based on RSF, and their predictive performances were measured by the C-index and the time-dependent cumulative/dynamics AUC (C/D AUC). RESULTS: In total, 6 radiomic features (5 for CT and 1 for PET) and 6 clinicopathologic features were selected. The radiomic, clinicopathologic and combination prognostic models yielded C-indexes of 0.9338, 0.9019 and 0.9527, and the mean values of the C/D AUC (mC/D AUC) were 0.9146, 0.8645 and 0.9199, respectively. CONCLUSIONS: PET/CT radiomics could achieve approval power in predicting DFS in early-stage uterine cervical squamous cancer. |
Databáze: | OpenAIRE |
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