Fragment Deconstruction of Small, Potent Factor Xa Inhibitors: Exploring the Superadditivity Energetics of Fragment Linking in Protein-Ligand Complexes
| Autor: | Herman Schreuder, Michael Wagner, Kurt Ritter, Jörg Czech, Matthias Urmann, Marc Nazaré, Hans Matter, David William Will, Armin Bauer, Volkmar Wehner |
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| Rok vydání: | 2011 |
| Předmět: |
chemistry.chemical_classification
Superadditivity Binding Sites Serine Proteinase Inhibitors medicine.drug_mechanism_of_action Stereochemistry Drug discovery Chemistry Factor Xa Inhibitor General Chemistry General Medicine Crystallography X-Ray Ligands Amides Catalysis Protein Structure Tertiary Molecular recognition Fragment (logic) Hydrolase Factor Xa medicine Non-covalent interactions Thermodynamics Protein ligand Factor Xa Inhibitors |
| Zdroj: | Angewandte Chemie. 124:929-935 |
| ISSN: | 0044-8249 |
| DOI: | 10.1002/ange.201107091 |
| Databáze: | OpenAIRE |
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