No Evidence of a Common DNA Variant Profile Specific to World Class Endurance Athletes
| Autor: | Dmitry G. Alexeev, Motohiko Miyachi, Marcel R. Boulay, Carlos A. Muniesa, Vladimir V. Uyba, Mark A. Sarzynski, Agnieszka Maciejewska-Karlowska, Nir Eynon, Takashi Kawahara, Bernd Wolfarth, Sujoy Ghosh, Catalina Santiago, Edward V. Generozov, Alejandro Lucia, Nickolay A. Kulemin, Ildus I. Ahmetov, Alexander V. Pavlenko, Guan Wang, Elena S. Kostryukova, Fleur C. Garton, Maxim L. Filipenko, Elena A. Ospanova, Peter J. Houweling, Sandosh Padmanabhan, Rainer Rauramaa, Claude Bouchard, Robert A. Scott, Haruka Murakami, Olga N. Pyankova, Kathryn N. North, Yannis P. Pitsiladis, Thomas Yvert, Louis Pérusse, Marek Sawczuk, Andrey K. Larin, Vadim M. Govorun, Noriyuki Fuku, Tuomo Rankinen, Paweł Cięszczyk |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Gerontology Male Physical fitness lcsh:Medicine Gene Expression Genome-wide association study Genética humana 600 Technik Medizin angewandte Wissenschaften::610 Medizin und Gesundheit 0302 clinical medicine Mathematical and Statistical Techniques Gene Frequency Medicine and Health Sciences Medicine Public and Occupational Health lcsh:Science Multidisciplinary Genomics Deporte Sports Science Research Design Meta-analysis Physical Sciences N-Acetylgalactosaminyltransferases Statistics (Mathematics) Research Article Sports Adult Genetic Markers DNA Copy Number Variations Replication Studies Single-nucleotide polymorphism Research and Analysis Methods Polymorphism Single Nucleotide 03 medical and health sciences Genetic Heterogeneity Oxygen Consumption Endurance training Genome-Wide Association Studies Genetics Humans Statistical Methods Molecular Biology Techniques Molecular Biology Alleles Sedentary lifestyle Genetic association Maximal Expiratory Flow Rate Behavior business.industry Genome Human lcsh:R Gene Mapping Biology and Life Sciences Computational Biology Cardiorespiratory fitness Human Genetics 030229 sport sciences Genome Analysis 030104 developmental biology Genetic Loci Physical Fitness Athletes Physical Endurance Recreation lcsh:Q Sedentary Behavior business Mathematics Meta-Analysis Genome-Wide Association Study |
| Zdroj: | Repositorio Institucional de la Consejería de Sanidad de la Comunidad de Madrid Consejería de Sanidad de la Comunidad de Madrid ABACUS. Repositorio de Producción Científica Universidad Europea (UEM) PLoS ONE PLoS ONE, Vol 11, Iss 1, p e0147330 (2016) |
| ISSN: | 1932-6203 |
| Popis: | There are strong genetic components to cardiorespiratory fitness and its response to exercise training. It would be useful to understand the differences in the genomic profile of highly trained endurance athletes of world class caliber and sedentary controls. An international consortium (GAMES) was established in order to compare elite endurance athletes and ethnicity-matched controls in a case-control study design. Genome-wide association studies were undertaken on two cohorts of elite endurance athletes and controls (GENATHLETE and Japanese endurance runners), from which a panel of 45 promising markers was identified. These markers were tested for replication in seven additional cohorts of endurance athletes and controls: from Australia, Ethiopia, Japan, Kenya, Poland, Russia and Spain. The study is based on a total of 1520 endurance athletes (835 who took part in endurance events in World Championships and/or Olympic Games) and 2760 controls. We hypothesized that world-class athletes are likely to be characterized by an even higher concentration of endurance performance alleles and we performed separate analyses on this subsample. The meta-analysis of all available studies revealed one statistically significant marker (rs558129 at GALNTL6 locus, p = 0.0002), even after correcting for multiple testing. As shown by the low heterogeneity index (I2 = 0), all eight cohorts showed the same direction of association with rs558129, even though p-values varied across the individual studies. In summary, this study did not identify a panel of genomic variants common to these elite endurance athlete groups. Since GAMES was underpowered to identify alleles with small effect sizes, some of the suggestive leads identified should be explored in expanded comparisons of world-class endurance athletes and sedentary controls and in tightly controlled exercise training studies. Such studies have the potential to illuminate the biology not only of world class endurance performance but also of compromised cardiac functions and cardiometabolic diseases. Fondo de Investigaciones Sanitarias (grant # PI12/00914). Research in sports genetics to A. Lucia in Spain was funded by grants from the Consejo Superior de Deportes (CSD) 2.806 JCR (2016) Q1, 15/64 Multidisciplinary Sciences No data SJR 2016 No data IDR 2016 UEM |
| Databáze: | OpenAIRE |
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