P173 COUPLED NITROSO-SULFIDE SIGNALIZATION TRIGGERS SPECIFIC VASOACTIVE EFFECTS IN INTRARENAL ARTERIES OF PATIENTS WITH ARTERIAL HYPERTENSION
| Autor: | Jan Breza, Karol Ondrias, Marian Grman, Frantisek Kristek, Andrea Berenyiova, Sona Cacanyiova |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
chemistry.chemical_classification
medicine.medical_specialty lcsh:Diseases of the circulatory (Cardiovascular) system Sulfide lcsh:Specialties of internal medicine business.industry General Medicine Nitroso chemistry.chemical_compound chemistry lcsh:RC581-951 lcsh:RC666-701 Vasoactive Internal medicine medicine Cardiology business Intrarenal arteries |
| Zdroj: | Artery Research, Vol 20 (2017) |
| ISSN: | 1876-4401 |
| Popis: | In normotensive conditions, it has been confirmed that S-nitrosothiols, as a source of NO, interact with hydrogen sulfide (H2S) and create new substance/s with specific vasoactive effects. This interaction could represent new regulator pathway also in hypertension. The aim of the study was to investigate the vasoactive effects of H2S, GSNO, and products of H2S/GSNO interaction in lobar arteries isolated from kidney after nephrectomy of patients suffering from arterial hypertension. Changes in isometric tension after pre-contraction were evaluated. Acetylcholine- induced vasorelaxation was significantly reduced compared to the effect induced by exogenous NO donor, sodium nitroprusside, probably suggesting an endothelium dysfunction. While 1 μmol/l Na2S had a minimal effect on the vascular tone, 20 μmol/l evoked a slight vasorelaxation. GSNO at 0.1 μmol/l induced vasorelaxation which was significantly smaller compared to the effect induced by 1μmol/l. The mixture of GSNO (0.1 μmol/l) and Na2S (1 μmol/l) induced significantly higher vasorelaxation compared to GSNO (0.1 μmol/l) alone only in 5th minute without the differences in the speed. On the other hand, the mixture prepared from higher concentrations of GSNO (1 μmol/l) and Na2S (10 μmol/l) induced a significantly higher (in 1st, 2nd, 5th, 10th minute) and faster vasorelaxation compared to the effect induced by GSNO (1 μmol/l) alone. In conditions of arterial hypertension H2S in interaction with GSNO regulated a vasoconstrictor-increased arterial tone towards of more pronounced vasorelaxation compared to GSNO alone. We confirmed for the first time that specific vasoactive effects of coupled nitroso-sulfide signalization were triggered also in human arterial tissue. |
| Databáze: | OpenAIRE |
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