Case report: a novel form of free protein S deficiency in an HIV-positive patient on hemodialysis
| Autor: | Marcus E. Carr, R. Michael Culpepper |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
Adult
Male medicine.drug_class medicine.medical_treatment HIV Infections Glomerulonephritis Membranous Protein S Antigen Renal Dialysis Immunopathology medicine Humans Glycoproteins biology business.industry Binding protein Anticoagulant Thrombosis General Medicine Blood Proteins medicine.disease Immunology biology.protein Hemodialysis business Nephrotic syndrome |
| Zdroj: | The American journal of the medical sciences. 303(6) |
| ISSN: | 0002-9629 |
| Popis: | Investigation of repetitive thrombotic episodes in an HIV-positive patient on maintenance hemodialysis revealed extraordinarily high levels of total (free plus protein bound) protein S antigen but severe reductions in free (interactive) protein S antigen. Patients with the nephrotic syndrome or chronic renal failure have shown elevations of total protein S antigen, associated with increased levels of the specific C4b-binding protein, yet have had normal free protein S antigen levels. Based on the fall in total and free protein S levels during hemodialysis treatments, the presence of normal levels of C4b-binding protein, and the coexistence of a polyclonal gammopathy, the authors infer the presence of a unique protein that binds protein S in this patient and that is not apparent in normal plasma. The anomalous association of protein S with this binding protein resulted in levels of free protein S antigen in the range of those reported in hereditary deficiencies of the anticoagulant. |
| Databáze: | OpenAIRE |
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