International Endocervical Adenocarcinoma Criteria and Classification (IECC): A New Pathogenetic Classification for Invasive Adenocarcinomas of the Endocervix
| Autor: | Malcolm C. Pike, Lien Hoang, Cristina Terinte, Prusha Patel, Simona Stolnicu, Esther Oliva, Iulia Barsan, Anna Pesci, Kay J. Park, Sarit Aviel-Ronen, Robert A. Soslow, Isabel Alvarado-Cabrero, Takako Kiyokawa |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Oncology medicine.medical_specialty Consensus Chromogenic in situ hybridization Uterine Cervical Neoplasms Adenocarcinoma Article Pathology and Forensic Medicine Diagnosis Differential 03 medical and health sciences 0302 clinical medicine Predictive Value of Tests Internal medicine Terminology as Topic Carcinoma Biomarkers Tumor Medicine Mucinous carcinoma Humans Neoplasm Invasiveness Papillomaviridae Cyclin-Dependent Kinase Inhibitor p16 In Situ Hybridization Tissue microarray business.industry Not Otherwise Specified Papillomavirus Infections medicine.disease Immunohistochemistry Endometrial Neoplasms Serous fluid 030104 developmental biology Tissue Array Analysis 030220 oncology & carcinogenesis Clear cell carcinoma RNA Viral Surgery Female Anatomy business |
| Zdroj: | The American journal of surgical pathology. 42(2) |
| ISSN: | 1532-0979 |
| Popis: | We sought to classify endocervical adenocarcinomas (ECAs) based on morphologic features linked to etiology (ie, human papillomavirus [HPV] infection), unlike the World Health Organization 2014 classification. The International Endocervical Adenocarcinoma Criteria and Classification (IECC criteria), described herein, distinguishes between human papillomavirus-associated adenocarcinoma (HPVA), recognized by the presence of luminal mitoses and apoptosis seen at scanning magnification, and no or limited HPVA features (nonhuman papillomavirus-associated adenocarcinoma [NHPVA]). HPVAs were then subcategorized based on cytoplasmic features (mostly to provide continuity with preexisting classification schemes), whereas NHPVAs were subclassified based on established criteria (ie, gastric-type, clear cell, etc.). Complete slide sets from 409 cases were collected from 7 institutions worldwide. Tissue microarrays representing 297 cases were constructed; immunohistochemistry (p16, p53, vimentin, progesterone receptor) and chromogenic in situ hybridization using an RNA-based probe set that recognizes 18 varieties of high-risk HPV were performed to validate IECC diagnoses. The 5 most common IECC diagnoses were usual-type (HPVA) (73% of cohort), gastric-type (NHPVA) (10%), mucinous adenocarcinoma of HPVA type, including intestinal, mucinous not otherwise specified, signet-ring, and invasive stratified mucin-producing carcinoma categories (9%), clear cell carcinoma (NHPVA) (3%) and adenocarcinoma, not otherwise specified (2%). Only 3 endometrioid carcinomas were recognized and all were NHPVA. When excluding cases thought to have suboptimal tissue processing, 90% and 95% of usual-type IECC cases overexpressed p16 and were HPV, whereas 37% and 3% of NHPVAs were p16 and HPV, respectively. The 1 HPV gastric-type carcinoma was found to have hybrid HPVA/NHPVA features on secondary review. NHPVA tumors were larger and occurred in significantly older patients, compared with HPVA tumors (P |
| Databáze: | OpenAIRE |
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