Active glottal closure during anoxic gasping in lambs
| Autor: | David Lemaire, François Thuot, Dominique Dorion, Patrick Létourneau, Jean-Paul Praud |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
Pulmonary and Respiratory Medicine
Glottis Physiology Hemodynamics Blood Pressure Biology Heart Rate Respiration medicine Animals Lung volumes Hypoxia Lung Eupnea Sheep Electromyography Apnea Electroencephalography respiratory system Carbon Dioxide Respiratory Muscles Oxygen medicine.anatomical_structure Animals Newborn Anesthesia Laryngeal Muscle Lactates Respiratory Mechanics Arterial blood Ketamine medicine.symptom Blood Gas Analysis Lung Volume Measurements Excitatory Amino Acid Antagonists |
| Zdroj: | Respiration physiology. 128(2) |
| ISSN: | 0034-5687 |
| Popis: | The present study was aimed at assessing laryngeal dynamics and their consequences during anoxic gasping in ketamine-sedated lambs. We first verified that the glottis was closed between gasps during anoxic gasping in seven chronically instrumented lambs, aged 11-15 days. Recording of glottal constrictor muscle electrical activity, subglottal pressure and lung volume, together with endoscopic observation, confirmed the presence of active glottal closure with maintenance of a high lung volume between gasps. Secondly, we tested whether maintenance of a high lung volume between gasps improved autoresuscitation efficiency. Six sedated lambs aged 8-11 days underwent two anoxic runs, including one with an open tracheostomy to prevent maintenance of a high lung volume. Access back to air was allowed for gasping. No significant difference was found in time to eupnea resumption, hemodynamic parameters or arterial blood gases. We conclude that a high lung volume is actively maintained by glottal closure between anoxic gasps in sedated lambs. Further studies are however needed to define the importance of laryngeal dynamics during gasping. |
| Databáze: | OpenAIRE |
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