Elderly Subjects Supplemented with L-Glutamine Shows an Improvement of Mucosal Immunity in the Upper Airways in Response to Influenza Virus Vaccination
| Autor: | Gislene R Amirato, Fernanda R. Monteiro, Tamaris Roseira, Edison Luiz Durigon, Fabyano Bruno Leal, Adriane Sperandio, André Luis Lacerda Bachi, Marcelo N. Rossi, Juliana de Melo Batista dos Santos, Danielle Bruna Leal Oliveira, Carlos A F Santos, Ewin B. Almeida, Rodolfo de Paula Vieira, Vitória Paixão, Jônatas Bussador do Amaral, Renier S. Pires, Mauro Vaisberg, Roberta Foster |
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| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Saliva Immunology L-glutamine lcsh:Medicine Article influenza virus Virus 03 medical and health sciences 0302 clinical medicine Immune system Immunity vaccine Drug Discovery antibodies Medicine Pharmacology (medical) Pharmacology biology business.industry lcsh:R Interleukin cytokines Vaccination Glutamine INTERLEUCINAS 030104 developmental biology Infectious Diseases biology.protein Antibody business immunoglobulin 030215 immunology |
| Zdroj: | Vaccines Volume 9 Issue 2 Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual) Universidade de São Paulo (USP) instacron:USP Vaccines, Vol 9, Iss 107, p 107 (2021) |
| ISSN: | 2076-393X |
| DOI: | 10.3390/vaccines9020107 |
| Popis: | Background: Although glutamine is able to improve the immune response, its action in the upper airway immunity against the influenza virus vaccine remains unclear. Therefore, we aimed to evaluate the L-glutamine supplementation effect on the mucosal immune/inflammatory response of elderly subjects vaccinated against the influenza virus. Methods: Saliva sampling from 83 physically active elderly volunteers were collected pre- and 30 days after influenza virus vaccination and supplementation with L-glutamine (Gln, n = 42) or placebo (PL, n = 41). Results: Gln group showed higher salivary levels of interleukin (IL)-17, total secretory immunoglobulin A (SIgA), and specific-SIgA post-vaccination than values found pre-vaccination and in the PL group post-vaccination. Whereas higher salivary levels of IL-6 and IL-10 were observed post-vaccination in the Gln group, IL-37 levels were lower post-vaccination in both groups than the values pre-vaccination. Tumor necrosis factor (TNF)-α levels were unchanged. Positive correlations between IL-6 and IL-10 were found in all volunteer groups pre- and post-vaccination and also between IL-17 and IL-6 or IL-10 in the Gln group post-vaccination. A negative correlation between IL-37 and IL-10 was found pre- and post-vaccination in the PL group. Conclusion: Gln supplementation was able to modulate salivary cytokine profile and increase SIgA levels, both total and specific to the influenza virus vaccine, in physically active elderly subjects. |
| Databáze: | OpenAIRE |
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