| Autor: |
Harry A. Drabkin, Philip H. Howe, Alessandro Lagana, Elizabeth Garrett-Mayer, Christopher Korch, Anna E. Barón, Xian Lu, Joëlle Roche, Vincent A. Potiron, Robert M. Gemmill, Patrick Nasarre |
| Rok vydání: |
2023 |
| DOI: |
10.1158/0008-5472.22396713 |
| Popis: |
PDF file - 1864K, NRP2 is stably up-regulated by TGFβ in lung cancer cells without increasing the halflife of mRNA or protein (S1); NRP2 up-regulation is blocked by inhibition of TβRI, AKT, ERK and ZEB1, but not by expression of inhibitory SMAD7 (S2); NRP2 knockdown blunts TGFβ-mediated transcriptional responses, ERK and AKT phosphorylation but does not influence SMAD activation (S3); NRP2 knockdown blocks cell scattering induced by TGFβ (S4); Immunohistochemical detection of NRP2 and cytokeratin in TGFβ exposed xenograft tumors with NRP2 or control knockdowns (S5); E-cadherin and NRP2 immunostaining of samples from a tumor microarray (S6); Predicted miRNA target sites in the 3' UTR of NRP2 and up-regulated NRP2 protein levels in hnRNP E1 knockdown cells (S7). |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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