Trends in Human Immunodeficiency Virus Type 1 (HIV‐1) Load among HIV‐1–Infected Children with Hemophilia
| Autor: | E A, Engels, P S, Rosenberg, H, Katki, J J, Goedert, R J, Biggar |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
Adult
Male Time Factors HIV Infections Hemophilia A Models Biological Virus Acquired immunodeficiency syndrome (AIDS) HIV Seropositivity medicine Humans Immunology and Allergy Seroconversion Sida HIV-1 Load biology Infant Viral Load biology.organism_classification medicine.disease Virology United States Infectious Diseases Child Preschool Lentivirus Immunology Disease Progression HIV-1 Regression Analysis Viral disease Viral load |
| Zdroj: | The Journal of Infectious Diseases. 184:364-368 |
| ISSN: | 1537-6613 0022-1899 |
| DOI: | 10.1086/322022 |
| Popis: | In human immunodeficiency virus type 1 (HIV-1)-infected persons, virus load (serum/ plasma level of HIV) predicts outcome. Virus load trends have been characterized in adults and infants but not in children. Virus load trends in 22 male children with hemophilia who acquired HIV-1 postnatally (age 0.7-5.2 years at seroconversion) were studied. The mean HIV-1 load 2 years after seroconversion was 4.40 log 10 copies/mL, and the mean change over time (slope) was 0.03 log 10 copies/(mL.year). Significant among-children variation was apparent: a random effects model predicted that 95% of children had early virus loads 3.75-5.04 log 10 copies/mL and slopes -0.07 to 0.12 log 10 copies/(mL.year). Higher early virus loads and higher slopes were each associated with increased mortality (P =.006 and P =.03, respectively). In conclusion, those subjects had virus load trends similar to those in adults. Early virus loads were lower than those in vertically infected infants, which suggests that factors changing soon after birth affect viral replication. |
| Databáze: | OpenAIRE |
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