Dietary excess regulates absorption and surface of gutepithelium through intestinal PPARα
| Autor: | Jordi Altirriba, Salvatore Fabbiano, Françoise Rohner-Jeanrenaud, Nicola Zamboni, Mirko Trajkovski, Dorothée Rigo, Martina Spiljar, Ozren Stojanović, Benedek Roska, Emilien Evrard, Pierre Maechler |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Male
medicine.medical_specialty Science Crypt General Physics and Astronomy Mice Transgenic Dietary excess General Biochemistry Genetics and Molecular Biology Article Perilipin-2 Eating Mice Downregulation and upregulation Internal medicine Lipid droplet medicine Animals Humans PPAR alpha Obesity ddc:612 Triglycerides Adiposity Multidisciplinary Triglyceride transport Chemistry digestive oral and skin physiology Lipid metabolism General Chemistry Small intestine Lipid Droplets Lipid Metabolism Postprandial Period Gut Epithelium Diet Fatty Liver Intestines Postprandial Endocrinology Gene Expression Regulation Intestinal Absorption Signal Transduction |
| Zdroj: | Nature Communications, 12 Nature Communications Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021) Nature communications, Vol. 12, No 1 (2021) P. 7031 |
| ISSN: | 2041-1723 |
| Popis: | Intestinal surface changes in size and function, but what propels these alterations and what are their metabolic consequences is unknown. Here we report that the food amount is a positive determinant of the gut surface area contributing to an increased absorptive function, reversible by reducing daily food. While several upregulated intestinal energetic pathways are dispensable, the intestinal PPAR alpha is instead necessary for the genetic and environment overeating-induced increase of the gut absorptive capacity. In presence of dietary lipids, intestinal PPAR alpha knock-out or its pharmacological antagonism suppress intestinal crypt expansion and shorten villi in mice and in human intestinal biopsies, diminishing the postprandial triglyceride transport and nutrient uptake. Intestinal PPAR alpha ablation limits systemic lipid absorption and restricts lipid droplet expansion and PLIN2 levels, critical for droplet formation. This improves the lipid metabolism, and reduces body adiposity and liver steatosis, suggesting an alternative target for treating obesity. Nature Communications, 12 ISSN:2041-1723 |
| Databáze: | OpenAIRE |
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