Statin-induced improvements in vulnerable plaques are attenuated in poorly controlled diabetic patients with coronary atherosclerosis disease: a serial optical coherence tomography analysis
| Autor: | Bo Yu, Rong Sun, Yefei Zhan, Meng Sun, Nana Dong, Jiannan Dai, Jinwei Tian, Wei Wang, Zulong Xie |
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| Rok vydání: | 2016 |
| Předmět: |
Male
China medicine.medical_specialty Statin medicine.drug_class Endocrinology Diabetes and Metabolism Drug Resistance 030209 endocrinology & metabolism Comorbidity Coronary Artery Disease 030204 cardiovascular system & hematology medicine.disease_cause Group A Group B Coronary artery disease 03 medical and health sciences 0302 clinical medicine Endocrinology Internal medicine Diabetes mellitus Diabetes Mellitus Internal Medicine medicine Humans Hypoglycemic Agents Aged Retrospective Studies Glycated Hemoglobin business.industry Retrospective cohort study General Medicine Middle Aged medicine.disease Vulnerable plaque Plaque Atherosclerotic Cardiology Female Hydroxymethylglutaryl-CoA Reductase Inhibitors business Tomography Optical Coherence |
| Zdroj: | Acta Diabetologica. 53:999-1008 |
| ISSN: | 1432-5233 0940-5429 |
| DOI: | 10.1007/s00592-016-0902-9 |
| Popis: | The incidence of cardiac events is increased in diabetic patients even after lipid-lowering therapy. This study aimed to compare the statin-induced changes in the characteristics of vulnerable plaques in patients without diabetes mellitus (DM) and in those with better- or poorly controlled DM, measured by optical coherence tomography (OCT). This was a retrospective study of 99 non-culprit lipid-rich plaques from 75 patients who underwent intensive OCT imaging examination. Thirty-four non-diabetic patients were assigned to Group A. According to the average HbA1c level, 22 diabetic patients were assigned to Group B, and 19, to Group C (average HbA1c |
| Databáze: | OpenAIRE |
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