Relationship Between Arterial Distensibility and Low-Frequency Power Spectrum of Blood Pressure in Spontaneously Hypertensive Rats
| Autor: | Michel E. Safar, Berthe Fournier, Patrick Lacolley, Kamel Chaouche-Teyara, Hubert Dabiré |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
Male
medicine.medical_specialty Mean arterial pressure Sympathetic nervous system Sympathetic Nervous System Carotid Artery Common Blood Pressure Urapidil Autonomic Nervous System Rats Inbred WKY Piperazines Rats Inbred SHR Flesinoxan Internal medicine Vascular Capacitance medicine Doxazosin Animals cardiovascular diseases Adrenergic alpha-Antagonists Pharmacology business.industry Echocardiography Doppler Rats Serotonin Receptor Agonists Autonomic nervous system Blood pressure Endocrinology medicine.anatomical_structure Receptors Serotonin Vascular resistance Cardiology and Cardiovascular Medicine business Receptors Serotonin 5-HT1 medicine.drug |
| Zdroj: | Journal of Cardiovascular Pharmacology. 39:98-106 |
| ISSN: | 0160-2446 |
| DOI: | 10.1097/00005344-200201000-00011 |
| Popis: | The aim of this study was to determine in spontaneously hypertensive rats (SHRs) whether a significant association may be observed between the low-frequency component of blood pressure variability (BPV) and arterial distensibility and to evaluate the role of the autonomic nervous system in this relationship. Doxazosin (1 mg/kg/d s.c.), flesinoxan (1 mg/kg/d s.c.), and urapidil (30 mg/kg/d s.c.) were infused over 24 h in SHRs. Blood pressure was recorded in conscious rats and BPV was characterized by spectral analysis. The distensibility-pressure curves for the carotid artery were determined by an ultrasonic echo-tracking device in anesthetized rats. Untreated SHRs had higher mean arterial pressure (MAP) and low-frequency MAP but a lower distensibility than normotensive Wistar-Kyoto rats. In SHRs inhibition of the autonomic nervous system by peripheral blockade of alpha1-adrenoceptors (doxazosin, 1 mg/kg, or urapidil, 30 mg/kg) or centrally mediated reduction of sympathetic tone (flesinoxan, 1 mg/kg) reduced MAP and low-frequency MAP in the conscious state and increased carotid operational distensibility in the anesthetized state. In these SHRs, we observed a negative association between low-frequency MAP and operational distensibility ( r = -0.48, p < 0.01). From multiple regression analysis, MAP and low-frequency MAP, but not drug treatment, influenced arterial distensibility. Our study in SHRs provides evidence for a strong association between increased low-frequency MAP and reduced arterial distensibility, with a common modulation provided by the autonomic nervous system via the alpha 1 -adrenergic receptor component and central nervous system. |
| Databáze: | OpenAIRE |
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