Infection of the central nervous system, sepsis and amyotrophic lateral sclerosis
| Autor: | Weimin Ye, Lars-Olof Ronnevi, Fang Fang, Tracy L. Peters, Ammar Al-Chalabi, Karin Wirdefeldt, Honglei Chen, Freya Kamel |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Předmět: |
medicine.medical_specialty
Critical Care and Emergency Medicine Epidemiology Population lcsh:Medicine Microbiology Motor Neuron Diseases Sepsis 03 medical and health sciences Central Nervous System Infections 0302 clinical medicine Infectious Diseases of the Nervous System Virology Internal medicine medicine Humans Clinical Epidemiology Amyotrophic lateral sclerosis education lcsh:Science Biology 030304 developmental biology Sweden 0303 health sciences education.field_of_study Multidisciplinary Proportional hazards model business.industry Amyotrophic Lateral Sclerosis Hazard ratio lcsh:R Case-control study Odds ratio medicine.disease Confidence interval 3. Good health Infectious Diseases Neurology Case-Control Studies Co-Infections Immunology Medicine lcsh:Q business 030217 neurology & neurosurgery Research Article |
| Zdroj: | PLoS ONE, Vol 6, Iss 12, p e29749 (2011) PLoS ONE PLoS ONE; Vol 6 |
| ISSN: | 1932-6203 |
| Popis: | Background Severe infections may lead to chronic inflammation in the central nervous system (CNS) which may in turn play a role in the etiopathogenesis of amyotrophic lateral sclerosis (ALS). The relentless progression and invasive supportive treatments of ALS may on the other hand induce severe infections among ALS patients. Methodology and Principal Findings The present study included 4,004 ALS patients identified from the Swedish Patient Register during 1991–2007 and 20,020 age and sex matched general population controls. Conditional logistic regression was used to estimate the odds ratios (ORs) of ALS given a previous hospitalization for CNS infection or sepsis. Cox models were used to estimate the hazard ratios (HRs) of hospitalization for CNS infection or sepsis after ALS diagnosis. Overall, previous CNS infection (OR: 1.3, 95% confidence interval [CI]: 0.8, 2.4) or sepsis (OR: 1.2, 95% CI: 0.9, 1.6) was not associated with ALS risk. However, compared to ALS free individuals, ALS cases were more likely to be hospitalized for sepsis after diagnosis (HR: 2.6, 95% CI: 1.9, 3.5). We did not observe a higher risk of CNS infection after ALS diagnosis. Conclusions/Significance Our results suggest that acute and severe infections unlikely contribute to the development of ALS; however, ALS patients are at a higher risk of sepsis after diagnosis, compared to ALS free individuals. |
| Databáze: | OpenAIRE |
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