[Evaluation of effect of supplementing Qi and activating blood decoction based on combined model of 'intestinal out-cardiac muscle cells' and discussion of its mechanism]
Autor: | Jingjing Zhang, Ya Geng, Defeng Li, Fangbo Zhang, Yi Zhang, Haiyu Xu, Yue-Xiang Ma, Hongjun Yang |
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Rok vydání: | 2016 |
Předmět: |
Qi
Decoction Absorption (skin) Pharmacology medicine.disease_cause medicine Animals Pharmacology (medical) Myocytes Cardiac General Pharmacology Toxicology and Pharmaceutics Oxidation resistance Cells Cultured Cardiac muscle cell Chemistry Myocardium Cardiac muscle Hydrogen Peroxide Rats Oxidative Stress medicine.anatomical_structure Complementary and alternative medicine Intestinal Absorption Blood circulation cardiovascular system Cellular Morphology Oxidative stress Drugs Chinese Herbal |
Zdroj: | Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 41(20) |
ISSN: | 1001-5302 |
Popis: | This research firstly establishes the oxidative damage model of H9c2 induced by H2O2 and screens the concentration range of intestines absorption liquid of Qi benefiting and blood circulation activating formula which possess external myocardium protection function. Then, the thesis chooses 4 dosages to conduct experiments:examining the protection function of intestines absorption liquid of Qi benefiting and blood circulation activating formula on H9c2 to provide reference for clinical prevention and curing of relative heart diseases of oxidative stress injury; as well as examining the H9c2 cardiac muscle cell vigour, cellular morphology, SOD, MDA and other indexes to primarily evaluate and discuss the functional mechanism of intestines absorption liquid of Qi benefiting and blood circulation activating formula. The results show that the intestines absorption liquid of Qi benefiting and blood circulation activating formula has relatively better protection function toward the H9c2 cardiac muscle cell damage induced by H2O2 and presents concentration dependency to some extent. The intestines absorption liquid of Qi benefiting and blood circulation activating formula can increase SOD vigour, and decrease MDA emission, thus decreasing the formation of abnormal cell and strengthening the oxidation resistance of cardiac muscle cell. The intestines absorption liquid of Qi benefiting and blood circulation activating formula has protection function to some extent. |
Databáze: | OpenAIRE |
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