Geniposide improves hepatic inflammation in diabetic db/db mice
| Autor: | Mengyun Zhou, Langen Zhuang, Xiaomei Zhang, Dongsheng Yu, Zhaoming Shi, Guoxi Jin, Xiaolei Hu |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Necrosis medicine.medical_treatment Immunology Anti-Inflammatory Agents Inflammation 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Internal medicine Diabetes Mellitus Animals Insulin Immunology and Allergy Medicine Iridoids Aspartate Aminotransferases Triglycerides Pharmacology Liver injury rho-Associated Kinases Triglyceride business.industry Fasudil Interleukin Alanine Transaminase medicine.disease Metformin Mice Inbred C57BL Cholesterol 030104 developmental biology Endocrinology Liver chemistry 030220 oncology & carcinogenesis Cytokines medicine.symptom business medicine.drug |
| Zdroj: | International Immunopharmacology. 59:141-147 |
| ISSN: | 1567-5769 |
| DOI: | 10.1016/j.intimp.2018.03.035 |
| Popis: | The current study was designed to investigate the protective role of geniposide (GE) in liver injury in diabetic C57BL/KsJ-db/db mice and to explore the underlying mechanisms. The oral glucose tolerance test was performed, and the levels of insulin, alanine aminotransferase (ALT), aspartate aminotransaminase (AST), total cholesterol (TC) and triglyceride (TG) were determined. The levels of the pro-inflammatory cytokines interleukin (IL)-1β, IL-6 and tumour necrosis factor-α were decreased by GE, metformin and fasudil in diabetic db/db mice. Western blotting analysis showed that the expression levels of Rho, ROCK1, ROCK2, p-NF-κBp65 and p-IκBα were significantly reversed by GE treatment. These findings demonstrated that GE exhibits a protective effect on diabetic hepatic inflammation. |
| Databáze: | OpenAIRE |
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