Phenoxybenzamine blockade in surgery of pheochromocytoma
| Autor: | Ashely E. Thomson, Andrus J. Voitk, Walley J. Temple, Allan R. Downs |
|---|---|
| Rok vydání: | 1977 |
| Předmět: |
Adult
medicine.medical_specialty Adolescent Phenoxybenzamine Adrenal Gland Neoplasms Hemodynamics Blood volume Pheochromocytoma Plasma volume Preoperative care Norepinephrine (medication) Norepinephrine Stable blood pressure Preoperative Care medicine Humans Blood Volume Adrenergic blockade business.industry Middle Aged medicine.disease Surgery Blockade Anesthesia Catecholamine business medicine.drug |
| Zdroj: | Journal of Surgical Research. 22:59-64 |
| ISSN: | 0022-4804 |
| DOI: | 10.1016/0022-4804(77)90125-1 |
| Popis: | A combination of oral and intravenous phenoxybenzamine block has been used at the University of Manitoba since 1958 in all elective operations on sympathetic amine-secreting tumors. A review of the last decade's (1965 to 1974, inclusive) experience reveals operations on 10 such patients. A preoperative diagnosis was made in eight cases, and the use of phenoxybenzamine in these eight cases is reviewed. Major fluctuations in hemodynamics during operative manipulation of tumor or following tumor removal were not observed in individuals receiving phenoxybenzamine in a dose of 1–3 mg/kg given 12 to 18 hr before operation. In those patients with high levels of catecholamine secretion, plasma volume expansion was sometimes required to sustain stable blood pressure during induction of the adrenergic blockade. However, no increased intraoperative requirements for transfusion occurred and no significant arrhythmias were detected on continuous monitoring. |
| Databáze: | OpenAIRE |
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