Different hemodynamics of basal ganglia between moyamoya and non-moyamoya diseases using intravoxel incoherent motion imaging and single-photon emission computed tomography

Autor: Koji Yamashita, Hiroshi Sugimori, Akira Nakamizo, Toshiyuki Amano, Takahiro Kuwashiro, Takeharu Watanabe, Keisuke Kawamata, Kiyomi Furuya, Shino Harada, Ryotaro Kamei, Junki Maehara, Yasushi Okada, Tomoyuki Noguchi
Rok vydání: 2022
Předmět:
Zdroj: Acta Radiologica. 64:769-775
ISSN: 1600-0455
0284-1851
Popis: Background Moyamoya disease (MMD) and non-MMD have different pathogenesis, clinical presentation, and treatment policy. Purpose To identify differences in hemodynamics between MMD and non-MMD using intravoxel incoherent motion (IVIM) magnetic resonance imaging (MRI) and single-photon emission computed tomography (SPECT). Material and Methods Patients who had undergone 99mTc-ECD or 123I-IMP SPECT, and IVIM imaging were retrospectively studied. IVIM imaging was acquired using six different b-values. Cerebral blood flow ratio (CBFR) in the basal ganglia was calculated using a standardized volume-of-interest template. The cerebellum was used as a reference region. IVIM perfusion fraction (f) was obtained using a two-step fitting algorithm. Elliptical regions of interest were placed in bilateral basal ganglia on the IVIM f map. Patients were classified into MMD and non-MMD groups. The correlation between CBFR and mean IVIM f (fmean) in the basal ganglia was evaluated using Spearman's rank correlation coefficient. Results In total, 20 patients with MMD and 28 non-MMD patients were analyzed. No significant differences in fmean were observed among MMD, affected hemisphere with non-MMD (non-MMDaff), and unaffected hemispheres with non-MMD (non-MMDunaff). A negative correlation was seen between fmean and CBFR in the MMD group (r = –0.40, P = 0.0108), but not in the non-MMD group (non-MMDaff, r = 0.07, P = 0.69; non-MMDunaff, r = –0.22, P = 0.29). No significant differences were found among MMD and non-MMD patients, irrespective of SPECT tracers. Conclusion The combination of IVIM MRI and SPECT appears to allow non-invasive identification of differences in hemodynamics between MMD and non-MMD.
Databáze: OpenAIRE
Externí odkaz: