Biologically Functionalized Expanded Polytetrafluoroethylene Blood Vessel Grafts
| Autor: | Qian Li, Yu-Jyun Lin, James A. Thomson, Lih-Sheng Turng, Dongfang Wang, Jue Zhang, George A. Schmidt, Yiyang Xu, Galip Yilmaz |
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| Rok vydání: | 2020 |
| Předmět: |
Pathology
medicine.medical_specialty Polymers and Plastics Heparin business.industry Biocompatible Materials Bioengineering Expanded polytetrafluoroethylene medicine.disease Bubonic plague Blood Vessel Prosthesis Biomaterials Human health surgical procedures operative medicine.anatomical_structure Materials Chemistry medicine Humans business Polytetrafluoroethylene Blood vessel |
| Zdroj: | Biomacromolecules. 21:3807-3816 |
| ISSN: | 1526-4602 1525-7797 |
| Popis: | Cardiovascular diseases plague human health because of the lack of transplantable small-diameter blood vessel (SDBV) grafts. Although expanded polytetrafluoroethylene (ePTFE) has the potential to be used as a biocompatible material for SDBV grafts, long-term patency is still the biggest challenge. As discussed in this paper, by virtue of a novel material formulation and a new and benign alcohol/water lubricating agent, biofunctionalized ePTFE blood vessel grafts aimed at providing long-term patency were fabricated. Compared to the most prevalent modification of PTFE, namely surface treatment, this method realized bulk treatment, which could guarantee homogeneous and long-lasting performance throughout PTFE products. These blood vessel grafts included embedded functional biomolecules, such as arginylglycylaspartic acid, heparin, and selenocystamine, using water as a solvent in paste extrusion and in the expansion of ePTFE. Fourier-transform infrared spectroscopy, X-ray photoelectron spectroscopy, and scanning electron microscope results confirmed the existence of these targeting biomolecules in the as-fabricated ePTFE blood vessel grafts. Meanwhile, the greatly improved biological functions of the grafts were demonstrated |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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