Risk factors for HTLV‐1, acute kidney injury, and urinary tract infection among aboriginal adults with end stage kidney disease in central Australia
| Autor: | Sajiv Cherian, Lloyd Einsiedel, Mohammad Radwanur Rahman Talukder, Richard J. Woodman, Cornelia Silke Clauss |
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| Rok vydání: | 2021 |
| Předmět: |
Adult
Male medicine.medical_specialty Native Hawaiian or Other Pacific Islander Urinary system Population Logistic regression Proviruses Risk Factors Virology Diabetes mellitus Internal medicine Odds Ratio medicine Humans Renal Insufficiency Chronic education Retrospective Studies Human T-lymphotropic virus 1 education.field_of_study business.industry Incidence Incidence (epidemiology) Racial Groups Australia Acute kidney injury Retrospective cohort study Acute Kidney Injury Middle Aged Viral Load medicine.disease HTLV-I Infections Cross-Sectional Studies Infectious Diseases Urinary Tract Infections Kidney Failure Chronic Female business Kidney disease |
| Zdroj: | Journal of Medical Virology. 93:6362-6370 |
| ISSN: | 1096-9071 0146-6615 |
| Popis: | Central Australia is a human T cell leukaemia virus type 1c (HTLV-1c) endemic region which has the highest incidence of chronic kidney disease (CKD) in Australia. Factors associated with HTLV-1 seropositivity among Aboriginal Australian adults with CKD receiving haemodialysis (HD) were determined. A retrospective observational study of Aboriginal adults (≥ 18 years) who were receiving regular haemodialysis (HD) at the two main dialysis units in Alice Springs, 1st December 2010 to 31st December 2015. Demographic and clinical data prior to commencing HD were extracted from hospital records from first presentation to Alice Springs Hospital (ASH) to HD commencement and associations were determined using logistic regression. Among 373 patients receiving HD, 133 (35.9%) were HTLV-1 infected. Identifiable factors associated with HTLV-1 status included increasing age, male gender and diabetes prior to HD. The odds of diabetes mellitus was significantly higher among patients with HTLV-1 (aOR 2.76, 95% CI 1.19, 6.39; p=0.017). More than one fifth of participants had an acute kidney injury, the risk of which was increased among those with a previous blood stream infection (aOR 3.02, 95% CI 1.71, 5.34, p |
| Databáze: | OpenAIRE |
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