A pan-cancer analysis confirms PTPN11’s potential as a prognostic and immunological biomarker

Autor: Yapeng, Cao, Haixia, Duan, Ailing, Su, Liran, Xu, Baochang, Lai
Rok vydání: 2022
Předmět:
Zdroj: Aging. 14:5590-5610
ISSN: 1945-4589
Popis: Protein tyrosine phosphatase, non-receptor type 11 (PTPN11) is a multifunctional tyrosine phosphatase and has a significant part in many types of tumors. As of yet, neither the expression profile of PTPN11 nor its significance in pan-cancer diagnosis has been clarified. With the assistance of The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO), we have comprehensively mapped the expression profiles, prognostic significance, genetic alteration, phosphorylation status, infiltration of immune cells, and functional properties of PTPN11 in 33 human tumors. There was an inconsistent expression of
Databáze: OpenAIRE