The effect of ticlopidine on canine platelets, fibrinogen, and antithrombin III activity
| Autor: | Lipscomb Dl, J. S. Spano, Mary K. Boudreaux, C. Jeffers |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
Blood Platelets
Antithrombin III Activity Serotonin medicine.medical_specialty Ticlopidine Platelet Aggregation Platelet aggregation Antithrombin III Fibrinogen Dogs Oral administration Internal medicine medicine Animals Platelet Mean platelet volume Pharmacology Dose-Response Relationship Drug General Veterinary Platelet Count Chemistry Adenosine Diphosphate Endocrinology Anesthesia Female Collagen Platelet Aggregation Inhibitors medicine.drug |
| Zdroj: | Journal of Veterinary Pharmacology and Therapeutics. 15:1-9 |
| ISSN: | 1365-2885 0140-7783 |
| Popis: | The effect of ticlopidine on platelet function, platelet number, mean platelet volume, antithrombin III activity, and fibrinogen was evaluated in 10 laboratory beagles. Ticlopidine (62 mg/kg) significantly inhibited ADP- and collagen-induced platelet aggregation within 2 days of the beginning of oral administration. Collagen-induced platelet 14C-serotonin release was not inhibited by day 9 of medication but was inhibited by day 20 in two of three beagles given medication for 32 days. Significant increases in mean platelet number were observed on days 2 and 5. The trend toward increased platelet number continued until day 16, at which time platelet number began to decrease toward baseline in three of three dogs treated for 32 days. Mean platelet volume (MPV) was significantly decreased compared to baseline on days 5 and 9. In three dogs treated for 32 clays, the lowest MPV was observed on day 9 in two dogs and on day 12 in one dog. Significant changes were not observed in antithrombin III activity or fibrinogen with ticlopicline treatment. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text