Cerebellar and premotor activity during a non-fatiguing grip task reflects motor fatigue in relapsing-remitting multiple sclerosis
| Autor: | Finn Selleberg, Olivia Svolgaard, Morten Blinkenberg, Kasper Winther Andersen, Hartwig R. Siebner, Christian Bauer, Kristoffer Hougaard Madsen |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Central Nervous System
Male 0301 basic medicine lcsh:Medicine Pathology and Laboratory Medicine Nervous System Brain mapping Material Fatigue Diagnostic Radiology Cognition 0302 clinical medicine Materials Physics Cerebellum Functional Magnetic Resonance Imaging Surveys and Questionnaires Medicine and Health Sciences Image Processing Computer-Assisted Hand Strength/physiology lcsh:Science Fatigue Motor skill Psychomotor Performance/physiology Cerebral Cortex Cognitive Impairment Brain Mapping Multidisciplinary Hand Strength medicine.diagnostic_test Cognitive Neurology Radiology and Imaging Physics Putamen Motor Cortex Brain Classical Mechanics Neurodegenerative Diseases Middle Aged Magnetic Resonance Imaging medicine.anatomical_structure Neurology Motor Skills Physical Sciences Muscle Fatigue Female Anatomy Research Article Adult medicine.medical_specialty Multiple Sclerosis Imaging Techniques Cognitive Neuroscience Immunology Materials Science Multiple Sclerosis Relapsing-Remitting/pathology Prefrontal Cortex Neuroimaging Research and Analysis Methods Cerebellum/diagnostic imaging Autoimmune Diseases Premotor cortex Young Adult 03 medical and health sciences Multiple Sclerosis Relapsing-Remitting Signs and Symptoms Physical medicine and rehabilitation Diagnostic Medicine Motor system medicine Humans Prefrontal Cortex/diagnostic imaging Brain/pathology Damage Mechanics Muscle fatigue business.industry Motor Cortex/diagnostic imaging Multiple sclerosis lcsh:R Biology and Life Sciences medicine.disease Demyelinating Disorders 030104 developmental biology Case-Control Studies Cognitive Science Clinical Immunology lcsh:Q Clinical Medicine Functional magnetic resonance imaging business Psychomotor Performance 030217 neurology & neurosurgery Neuroscience |
| Zdroj: | PLoS ONE, Vol 13, Iss 10, p e0201162 (2018) Svolgaard, O, Andersen, K W, Bauer, C, Madsen, K H, Blinkenberg, M, Selleberg, F & Siebner, H R 2018, ' Cerebellar and premotor activity during a non-fatiguing grip task reflects motor fatigue in relapsing-remitting multiple sclerosis ', PLoS ONE, vol. 13, no. 10, e0201162 . https://doi.org/10.1371/journal.pone.0201162 Svolgaard, O, Andersen, K W, Bauer, C, Madsen, K H, Blinkenberg, M, Selleberg, F & Siebner, H R 2018, ' Cerebellar and premotor activity during a non-fatiguing grip task reflects motor fatigue in relapsing-remitting multiple sclerosis ', PLOS ONE, vol. 13, no. 10, e0201162 . https://doi.org/10.1371/journal.pone.0201162 PLoS ONE |
| ISSN: | 1932-6203 |
| DOI: | 10.1371/journal.pone.0201162 |
| Popis: | Fatigue is a common and highly disabling symptom of multiple sclerosis. Patients experience an effort-independent general subjective feeling of fatigue as well as excessive fatigability when engaging in physical or mental activity. Previous research using functional magnetic resonance imaging (fMRI) has revealed heterogeneous findings, but some evidence implicates the motor system. To identify brain correlates of fatigue, 44 mildly impaired patients with relapsing-remitting multiple sclerosis and 25 age- and gender-matched healthy controls underwent functional magnetic resonance imaging at 3 Tesla, while they performed alternating blocks of rest and a non-fatiguing precision grip task. We investigated neural correlates of fatigue using the motor subscore of Fatigue Scale for Motor and Cognitive Functions (FSMCMOTOR) using the bilateral motor cerebellum, putamen, and dorsal premotor cortex as regions of interest. Patients and healthy controls performed the grip force task equally well without being fatigued. In patients, task-related activity in lobule VI of right motor cerebellum changed in proportion with individual FSMCMOTOR scores. In right dorsal premotor cortex, linear increases in activity across consecutive task blocks scaled with individual FSMCMOTOR scores in healthy controls, but not in patients. In premotor and dorsomedial prefrontal areas, patients were impaired at upscaling task-related activity the more they were affected by motor fatigue. The results support the notion that increased sensorimotor processing in the cerebellum contributes to the experience of motor fatigue and fatigability in multiple sclerosis. Additionally, downscaling of motivational input or sensorimotor processing in prefrontal and premotor areas may constitute an additional pathophysiological factor. |
| Databáze: | OpenAIRE |
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