Dosage Compensation in Drosophila—a Model for the Coordinate Regulation of Transcription
| Autor: | Andres Hilfiker, Mitzi I. Kuroda, John C. Lucchesi |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Male
0301 basic medicine X Chromosome Transcription Genetic Boveri–Sutton chromosome theory Biology Y chromosome Evolution Molecular Chromosome segregation 03 medical and health sciences 0302 clinical medicine Dosage Compensation Genetic Y Chromosome Genetics Animals Drosophila Proteins X chromosome Polytene Chromosomes Dosage compensation Polytene chromosome Classical genetics Chromosome FlyBook Drosophila melanogaster 030104 developmental biology 030217 neurology & neurosurgery |
| Zdroj: | Genetics. 204:435-450 |
| ISSN: | 1943-2631 |
| DOI: | 10.1534/genetics.115.185108 |
| Popis: | The sex chromosomes have special significance in the history of genetics. The chromosomal basis of inheritance was firmly established when Calvin Bridges demonstrated that exceptions to Mendel’s laws of segregation were accompanied at the cytological level by exceptional sex chromosome segregation. The morphological differences between X and Y exploited in Bridges’ experiments arose as a consequence of the evolution of the sex chromosomes. Originally a homologous chromosome pair, the degeneration of the Y chromosome has been accompanied by a requirement for increased expression of the single X chromosome in males. Drosophila has been a model for the study of this dosage compensation and has brought key strengths, including classical genetics, the exceptional cytology of polytene chromosomes, and more recently, comprehensive genomics. The impact of these studies goes beyond sex chromosome regulation, providing valuable insights into mechanisms for the establishment and maintenance of chromatin domains, and for the coordinate regulation of transcription. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|