Prognostic Implications of Parathyroid Hormone-Related Protein in Males and Females With Non–Small-Cell Lung Cancer
| Autor: | Randolph H. Hastings, Rick Quintana, Ann Tipps, Douglas A. Arenberg, Shannon Carskadon, Leonard J. Deftos, Philippe R. Montgrain |
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| Rok vydání: | 2011 |
| Předmět: |
Male
Pulmonary and Respiratory Medicine Cancer Research medicine.medical_specialty Pathology Lung Neoplasms Disease Gastroenterology Carcinoma Non-Small-Cell Lung Internal medicine medicine Carcinoma Humans Stage (cooking) Lung cancer Aged Neoplasm Staging Sex Characteristics Lung Parathyroid hormone-related protein business.industry Parathyroid Hormone-Related Protein Middle Aged Prognosis medicine.disease Immunohistochemistry medicine.anatomical_structure Oncology Female business Sex characteristics |
| Zdroj: | Clinical Lung Cancer. 12:197-205 |
| ISSN: | 1525-7304 |
| DOI: | 10.1016/j.cllc.2011.03.018 |
| Popis: | Non-small-cell lung carcinoma immunoreactivity for parathyroid hormone-related protein has been associated with increased survival in female patients but not in male patients. The current investigation attempted to substantiate this finding in 2 new patient groups.Patients were divided into groups with and without immunoreactivity for a carboxyl-terminal parathyroid hormone-related protein epitope assessed in deparaffinized sections by a blinded observer. One group included 85 female patients with stage I lung cancer, and the second group had 48 female and 66 male patients with stage I-IV lung cancer. Survival times were compared by the log-rank test between groups separated by tumor parathyroid hormone-related protein status.Parathyroid hormone-related protein was present in 70%-80% of the patients, independent of sex, stage, and smoking history. In the females with stage I lung cancer, parathyroid hormone-related protein increased median survival from 25 to 60 months (P.05). In the second group, parathyroid hormone-related protein expression increased 48-month disease-free survival of female lung cancer patients from 44% to 63% (P.05), but had no effect in male patients. Parathyroid hormone-related protein remained a significant, independent predictor when evaluated together with other covariates by Cox multivariate regression.This study verifies that parathyroid hormone-related protein is a sex-dependent survival factor for non-small-cell lung carcinoma, that it correlates with disease-free survival, and that the association with survival holds for women with early-stage disease as well as more advanced cancer. Thus, the protein could find use as a prognostic indicator and could be a target for therapy. |
| Databáze: | OpenAIRE |
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