Lipid Bilayer Disruption by Amphiphilic Janus Nanoparticles: The Role of Janus Balance
| Autor: | Yan Yu, Kwahun Lee |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Chemistry
Nanoparticle Janus particles 02 engineering and technology Surfaces and Interfaces 010402 general chemistry 021001 nanoscience & nanotechnology Condensed Matter Physics 01 natural sciences 0104 chemical sciences Membrane Amphiphile Electrochemistry Biophysics Particle General Materials Science Janus Surface charge 0210 nano-technology Lipid bilayer Spectroscopy |
| Zdroj: | Langmuir. 34:12387-12393 |
| ISSN: | 1520-5827 0743-7463 |
| DOI: | 10.1021/acs.langmuir.8b02298 |
| Popis: | Amphiphilic nanoparticles are known to cause defects in lipid bilayers. However, we have shown recently that their disruptive effects are significantly enhanced when surface charges and hydrophobic groups are spatially segregated on opposite hemispheres of a single particle. Using the same amphiphilic cationic/hydrophobic Janus particle system, here we investigate the role of the hydrophilic-lipophilic balance of the particles (namely the Janus balance) in their interaction with zwitterionic lipid bilayers. We show that Janus nanoparticles induce holes in lipid bilayers only when the hydrophobic side of particles occupies 20% or more of their surfaces. Beyond this threshold, the larger the hydrophobic surface area, the more attractive the particles are to lipid bilayers, and a lower particle concentration is needed for causing defects in the bilayers. The results establish a quantitative relationship between the surface coverage of hydrophobicity on the Janus particles and the particle-induced disruption to the lipid membranes. |
| Databáze: | OpenAIRE |
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