Influence of HLA matching and blood-transfusion on outcome of 502 London Transplant Group renal-graft recipients
| Autor: | J.A Sachs, A.M.I Paris, J.F. Moorhead, H Festenstein, G. D. Pegrum |
|---|---|
| Rok vydání: | 1976 |
| Předmět: |
Graft Rejection
Male medicine.medical_specialty Blood transfusion Time Factors medicine.medical_treatment Renal graft Human leukocyte antigen Cadaver kidney Kidney Sex Factors HLA Antigens Histocompatibility Antigens London Preoperative Care Medicine Humans Transplantation Homologous Blood Transfusion business.industry Histocompatibility Testing General Medicine Kidney Transplantation Tissue Donors Surgery Transplantation Evaluation Studies as Topic Graft survival Female Binding Sites Antibody business Follow-Up Studies |
| Zdroj: | Lancet (London, England). 1(7952) |
| ISSN: | 0140-6736 |
| Popis: | The outcome of 502 cadaver kidney transplants has been followed for up to six years; these grafts were arranged through the Tissue Immunology Unit of the London Hospital Medical College, the coordinating centre of the London Transplant Group. An analysis of HLA (A and B) recipient-donor matching revealed, as in previous analyses, clear differences (now highly significant) between the best as compared with the lesser matched recipients. A quarter of the patients (group 4 and 3a) had a superior outcome 20-30% greater than poorly matched (2 or less group) which constituted 53% of individuals. The results in the 3b group (28% of patients) were intermediate 10-15% better than the "2 or less antigens in common" group. A small number of recipients mostly 4 or 3 matched who were retrospectively HLA-D matched showed an even better graft survival. The effect of blood-transfusion before transplantation was studied and found to improve the outlook especially in the best-matched groups. No difference was apparent between those receiving less or more than ten units except in a group of patients with cytotoxic antibodies and/or retransplants. This "immunocompetent-presensitised" group had the best outcome provided these recipients had few transfusions and were subsequently well matched. These findings emphasise the continued need for successful collaborative associations, so that improved matching can be achieved which if universally applied would ensure better graft survival for a large number of patients in renal failure. |
| Databáze: | OpenAIRE |
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