Biodegradable nanoparticles for improved kidney bioavailability of rhein: preparation, characterization, plasma, and kidney pharmacokinetics
| Autor: | Jianping Ma, Yinghui Wei, Fanzhu Li, Xiaoting Luo, Jiani Guan, Jingwen Luo, Yicong Zhong |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Microdialysis
Biological Availability Pharmaceutical Science Nanoparticle Anthraquinones 02 engineering and technology Pharmacology Kidney 03 medical and health sciences Drug Delivery Systems 0302 clinical medicine Pharmacokinetics Drug Discovery medicine Animals Chromatography Chemistry Organic Chemistry Biodegradable nanoparticles 021001 nanoscience & nanotechnology In vitro Rats Bioavailability medicine.anatomical_structure 030220 oncology & carcinogenesis Nanoparticles Particle size 0210 nano-technology |
| Zdroj: | Drug Development and Industrial Pharmacy. 43:1885-1891 |
| ISSN: | 1520-5762 0363-9045 |
| DOI: | 10.1080/03639045.2017.1353519 |
| Popis: | The aim of this work is to develop biodegradable nanoparticles for improved kidney bioavailability of rhein (RH). RH-loaded nanoparticles were prepared using an emulsification solvent evaporation method and fully characterized by several techniques. Kidney pharmacokinetics was assessed by implanting a microdialysis probe in rat's kidney cortex. Blood samples were simultaneously collected (via femoral artery) for assessing plasma pharmacokinetics. Optimized nanoparticles were small, with a mean particle size of 132.6 ± 5.95 nm, and homogeneously dispersed. The charge on the particles was nearly zero, the encapsulation efficiency was 62.71 ± 3.02%, and the drug loading was 1.56 ± 0.15%. In vitro release of RH from the nanoparticles showed an initial burst release followed by a sustained release. Plasma and kidney pharmacokinetics showed that encapsulation of RH into nanoparticles significantly increased its kidney bioavailability (AUCkidney/AUCplasma = 0.586 ± 0.072), clearly indicating that nanopar... |
| Databáze: | OpenAIRE |
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