Cardiac baroreflex dysfunction in patients with pulmonary arterial hypertension at rest and during orthostatic stress: role of the peripheral chemoreflex
| Autor: | Camila M. Costa, Liliane Cunha Aranda, Sergio L. Cravo, Michael K. Stickland, Marcelle Paula-Ribeiro, Talita M. Silva, Luiz Eduardo Nery, Roberta Pulcheri Ramos, Jaquelina S. Ota-Arakaki, Bruno M. Silva, Indyanara C. Ribeiro |
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| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Physiology Blood Pressure Baroreflex Heart Rate Physiology (medical) Internal medicine medicine Humans In patient Rest (music) Pulmonary Arterial Hypertension Cardiac baroreflex business.industry musculoskeletal neural and ocular physiology medicine.disease Pulmonary hypertension Chemoreceptor Cells Autonomic nervous system medicine.anatomical_structure cardiovascular system Cardiology Carotid body business circulatory and respiratory physiology Peripheral chemoreflex |
| Zdroj: | Journal of Applied Physiology. 131:794-807 |
| ISSN: | 1522-1601 8750-7587 |
| DOI: | 10.1152/japplphysiol.00152.2021 |
| Popis: | Does the peripheral chemoreflex play a role in cardiac baroreflex dysfunction in patients with pulmonary arterial hypertension (PAH)? Here we provide new evidence of cardiac baroreflex dysfunction under spontaneous and, most notably, provoked blood pressure fluctuations in patients with nonhypoxemic PAH. Importantly, impaired cardiac baroreflex effectiveness during provoked blood pressure fluctuations was independently associated with poorer functional capacity. Finally, our results indicated that the peripheral chemoreflex did not mediate cardiac baroreflex dysfunction among those patients. |
| Databáze: | OpenAIRE |
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