Effects of vilazodone on suicidal ideation and behavior in adults with major depressive disorder or generalized anxiety disorder
| Autor: | Changzheng Chen, Michael E. Thase, Maju Mathews, John Edwards, Carl Gommoll, Suresh Durgam, Cheng-Tao Chang |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Adult
Male medicine.medical_specialty Generalized anxiety disorder Vilazodone Hydrochloride suicidal behavior Suicide Attempted Placebo Suicidal Ideation Young Adult 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Double-Blind Method Vilazodone Post-hoc analysis medicine Humans Pharmacology (medical) Psychiatry generalized anxiety disorder Suicidal ideation Randomized Controlled Trials as Topic Depressive Disorder Major antidepressant major depressive disorder Original Articles medicine.disease Anxiety Disorders 030227 psychiatry Psychiatry and Mental health chemistry vilazodone Meta-analysis Antidepressant Major depressive disorder Female medicine.symptom Psychology Selective Serotonin Reuptake Inhibitors 030217 neurology & neurosurgery Clinical psychology |
| Zdroj: | International Clinical Psychopharmacology |
| ISSN: | 0268-1315 |
| DOI: | 10.1097/yic.0000000000000180 |
| Popis: | Treatment-emergent suicidal ideation and behavior are ongoing concerns with antidepressants. Vilazodone, currently approved for the treatment of major depressive disorder (MDD) in adults, has also been evaluated in generalized anxiety disorder (GAD). Post-hoc analyses of vilazodone trials were carried out to examine its effects on suicidal ideation and behavior in adults with MDD or GAD. Data were pooled from vilazodone trials in MDD (four studies) and GAD (three studies). The incidence of suicide-related events was analyzed on the basis of treatment-emergent adverse event reporting and Columbia-Suicide Severity Rating Scale (C-SSRS) monitoring. Treatment-emergent suicidal ideation was analyzed on the basis of a C-SSRS category shift from no suicidal ideation/behavior (C-SSRS=0) at baseline to suicide ideation (C-SSRS=1-5) during treatment. In pooled safety populations (MDD, n=2233; GAD, n=1475), suicide-related treatment-emergent adverse events occurred in less than 1% of vilazodone-treated and placebo-treated patients. Incidences of C-SSRS suicidal ideation were as follows: MDD (vilazodone=19.9%, placebo=24.7%); GAD (vilazodone=7.7%, placebo=9.4%). Shifts from no suicidal ideation/behavior at baseline to suicidal ideation during treatment were as follows: MDD (vilazodone=9.4%, placebo=10.3%); GAD (vilazodone=4.4%, placebo=6.1%). Data from placebo-controlled studies indicate little or no risk of treatment-emergent suicidal ideation or behavior with vilazodone in adults with MDD or GAD. Nevertheless, all patients should be monitored for suicidal thoughts and behaviors during antidepressant treatment. |
| Databáze: | OpenAIRE |
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