In Vivo Pulmonary Toxicity of Cellulose in Rats
| Autor: | Erzsébet Tátrai, György Ungváry, Z. Adamis, Katalin Merétey, Márta Brózik |
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| Rok vydání: | 1996 |
| Předmět: |
Male
Pathology medicine.medical_specialty Lung medicine.diagnostic_test Pulmonary toxicity Pulmonary Fibrosis Asbestos Crocidolite Type-II Pneumocytes Respiratory disease Biology Toxicology medicine.disease Immunoglobulin A Rats Bronchoalveolar lavage medicine.anatomical_structure Toxicity Pulmonary fibrosis medicine Animals Type-I Pneumocytes Cellulose Bronchoalveolar Lavage Fluid |
| Zdroj: | Journal of Applied Toxicology. 16:129-135 |
| ISSN: | 1099-1263 0260-437X |
| DOI: | 10.1002/(sici)1099-1263(199603)16:2<129::aid-jat316>3.0.co;2-c |
| Popis: | Cellulose after a single intratracheal dose (15 mg per animal) brought about fibrosing granulomatous alveobronchiolitis and an increase of IgA production in the bronchoalveolar lavage. Fibrosing alveolitis showed moderate progression as a function of time. With different morphological methods, injury of type I pneumocytes and the incomplete repair of type II pneumocytes were detected. The damage of the alveolar epithelium initiated and activated a series of processes that led to definite pulmonary alterations: pulmonary fibrosis leading to the disintegration of the alveolo-capillary morphological functional unit. |
| Databáze: | OpenAIRE |
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