Near-infrared light-activated IR780-loaded liposomes for anti-tumor angiogenesis and Photothermal therapy

Autor: Xue Yang, Minjie Sun, Yuxin Guo, Chenzi Li, Fang Gao, Huipeng Li, Kaikai Wang, David Oupicky, Ying Yang, Chenggen Qian
Rok vydání: 2018
Předmět:
0301 basic medicine
Indoles
Angiogenesis
Biomedical Engineering
Mice
Nude
Pharmaceutical Science
Medicine (miscellaneous)
Angiogenesis Inhibitors
Apoptosis
Breast Neoplasms
Bioengineering
02 engineering and technology
Mice
03 medical and health sciences
Drug Delivery Systems
Cell Movement
In vivo
Sunitinib
Tumor Cells
Cultured
medicine
Animals
Humans
General Materials Science
Cell Proliferation
Drug Carriers
Mice
Inbred BALB C
Liposome
Spectroscopy
Near-Infrared
Neovascularization
Pathologic
Chemistry
Lasers
Hyperthermia
Induced
Phototherapy
Photothermal therapy
021001 nanoscience & nanotechnology
Combined Modality Therapy
Xenograft Model Antitumor Assays
Controlled release
030104 developmental biology
Liposomes
Drug delivery
Cancer cell
Cancer research
Molecular Medicine
Female
0210 nano-technology
medicine.drug
Zdroj: Nanomedicine: Nanotechnology, Biology and Medicine. 14:2283-2294
ISSN: 1549-9634
DOI: 10.1016/j.nano.2018.06.011
Popis: Tumor angiogenesis is a key step in the process of tumor development, and antitumor angiogenesis has a profound influence on tumor growth. Herein we report a dual-function drug delivery system comprising a Near-infrared (NIR) dye and an anti-angiogenic drug within liposomes (Lip-IR780-Sunitinib) for enhanced antitumor therapy. The hydrophobic NIR dye IR780 was loaded into the liposome phospholipid bilayer, and the bilayer would be disrupted by laser irradiation so that anti-angiogenic drug sunitinib release would be activated remotely at the tumor site. The released hydrophilic sunitinib could potentially target multiple VEGF receptors on the tumor endothelial cell surface to inhibit angiogenesis. Meanwhile, IR780-loaded liposomes kill the cancer cells by photothermal therapy. Lip-IR780-Sunitinib exhibited enhanced anti-tumor and anti-angiogenic effects in vitro and in vivo. This system facilitates easy and controlled release of cargos to achieve anti-tumor angiogenesis and photothermal therapy.
Databáze: OpenAIRE
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