EGFR mutations and human papillomavirus in lung cancer
| Autor: | Masakazu Yanagi, Naoya Yokomakura, Takuya Kato, Suminori Akiba, Masami Sato, Tsutomu Hamada, Hiromasa Inoue, Noureen Khan, Takuya Samukawa, Shoji Natsugoe, Chihaya Koriyama, Takeshi Otsuka |
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| Rok vydání: | 2012 |
| Předmět: |
Male
Pulmonary and Respiratory Medicine Oncology Cancer Research medicine.medical_specialty Lung Neoplasms Adenocarcinoma medicine.disease_cause Gefitinib Internal medicine medicine Carcinoma Humans Epidermal growth factor receptor Lung cancer Gene Aged Human papillomavirus 16 Mutation Lung biology business.industry Papillomavirus Infections virus diseases Viral Load medicine.disease ErbB Receptors medicine.anatomical_structure Carcinoma Squamous Cell biology.protein Female business medicine.drug |
| Zdroj: | Lung Cancer. 78:144-147 |
| ISSN: | 0169-5002 |
| Popis: | Our previous study reported a frequent detection of human papillomavirus (HPV) genome in primary lung adenocarcinomas of the recurrent patients who were responsive to epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitor, suggesting that HPV presence in lung cancer may be related to a genetic background related to EGFR mutations. The present study examined the association between the HPV presence and mutations in exons 19 and 21 of EGFR gene in Japanese lung cancer patients. Thirteen (31%) out of 42 cases had EGFR mutations. Although these mutations were tended to be observed in females, non-smokers, or adenocarcinomas, there was no statistically significant associations. HPV DNA was found in 7/42 (17%) lung tumors. The frequency of HPV presence did not differ in histological types. The presence of HPV DNA was significantly related to EGFR mutations (P=0.021), especially in adenocarcinomas of the lung (P=0.014). HPV-positive lung tumors accounted for 38% and 7% of those with and without EGFR mutations, respectively. Our results suggest that EGFR mutations are associated with HPV presence in Japanese patients with lung cancer. |
| Databáze: | OpenAIRE |
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